Product Name
SLC36A2, Polyclonal Antibody
Full Product Name
SLC36A2 Antibody; HRP conjugated
Product Synonym Names
Proton-coupled amino acid transporter 2; Proton/amino acid transporter 2; Solute carrier family 36 member 2; Tramdorin-1; SLC36A2; PAT2; TRAMD1
Product Gene Name
anti-SLC36A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q495M3
Purity/Purification
>95%,Protein G purified
Immunogen
Recombinant human Proton-coupled amino acid transporter 2 protein
Storage Buffer
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Preparation and Storage
Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SLC36A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC36A2 antibody
Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine.
Applications Tested/Suitable for anti-SLC36A2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SLC36A2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_861441.2
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NCBI GenBank Nucleotide #
NM_181776.2
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UniProt Primary Accession #
Q495M3
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UniProt Secondary Accession #
Q495M4; Q495M6; Q6ZWK5; Q7Z6B5[Other Products]
UniProt Related Accession #
Q495M3[Other Products]
Molecular Weight
22,680 Da
NCBI Official Full Name
proton-coupled amino acid transporter 2
NCBI Official Synonym Full Names
solute carrier family 36 (proton/amino acid symporter), member 2
NCBI Official Symbol
SLC36A2 [Similar Products]
NCBI Official Synonym Symbols
PAT2; TRAMD1
[Similar Products]
NCBI Protein Information
proton-coupled amino acid transporter 2
UniProt Protein Name
Proton-coupled amino acid transporter 2
UniProt Synonym Protein Names
Solute carrier family 36 member 2; Tramdorin-1
Protein Family
Proton-coupled amino acid transporter
UniProt Gene Name
SLC36A2 [Similar Products]
UniProt Synonym Gene Names
PAT2; TRAMD1; Proton/amino acid transporter 2 [Similar Products]
UniProt Entry Name
S36A2_HUMAN
NCBI Summary for SLC36A2
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
UniProt Comments for SLC36A2
SLC36A2: Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine. Defects in SLC36A2 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC36A2 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Mutations in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families. Belongs to the amino acid/polyamine transporter 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: cytoplasm; integral to membrane; plasma membrane
Molecular Function: glycine transmembrane transporter activity; hydrogen ion transmembrane transporter activity; hydrogen:amino acid symporter activity; L-alanine transmembrane transporter activity; L-proline transmembrane transporter activity
Biological Process: amino acid transport; glycine transport; ion transport; L-alanine transport; transmembrane transport
Disease: Hyperglycinuria; Iminoglycinuria
Research Articles on SLC36A2
1. The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.
Precautions
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Disclaimer
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