Full Product Name
Mouse monoclonal CD1c antibody
Product Synonym Names
CD1c antibody
Product Gene Name
anti-CD1c antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29017
Purity/Purification
Purified by affinity chromatography.
Form/Format
Supplied as liquid in PBS with 0.02% sodium azide
Concentration
1 mg/ml (lot specific)
Immunogen
CD1c antibody was raised in Mouse using MOLT 4 cell line as the immunogen
Preparation and Storage
Store as concentrated solution. Aliquot and store at -20 degree C or below. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-CD1c antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CD1c antibody
Immunology
Applications Tested/Suitable for anti-CD1c antibody
Immunohistochemistry (IHC), Immunoprecipitation (IP), Radioimmunoassay (RIA)
NCBI/Uniprot data below describe general gene information for CD1c. It may not necessarily be applicable to this product.
NCBI Accession #
CAG33361.1
[Other Products]
UniProt Primary Accession #
P29017
[Other Products]
UniProt Secondary Accession #
Q5TDJ7; Q6IAS4; Q9UMM0; Q9UN96[Other Products]
UniProt Related Accession #
P29017[Other Products]
Molecular Weight
37,654 Da
NCBI Official Full Name
CD1C
NCBI Official Synonym Full Names
CD1c molecule
NCBI Official Symbol
CD1C [Similar Products]
NCBI Official Synonym Symbols
R7; CD1; CD1A; BDCA1
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NCBI Protein Information
T-cell surface glycoprotein CD1c
UniProt Protein Name
T-cell surface glycoprotein CD1c
UniProt Synonym Protein Names
CD_antigen: CD1c
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD1C [Similar Products]
NCBI Summary for CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
UniProt Comments for CD1c
CD1C: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; glycolipid binding
Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response; T cell activation during immune response
Research Articles on CD1c
1. Stressed beta-cells have little effect on human BDCA1-expressed dendritic cells activation and function, while enterovirus-infected beta-cells impact these cells significantly.
Precautions
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Disclaimer
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