Product Name
PF4V1, Recombinant Protein
Full Product Name
Human PF4V1 Protein (Fc Tag)
Product Synonym Names
PF4V1
Product Gene Name
PF4V1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10720
Purity/Purification
> 85 % as determined by SDS-PAGE.
Form/Format
Lyophilized from sterile PBS, pH 7.4
Predicted N Terminal
Phe 31
Endotoxin
<1.0 EU per mug protein as determined by the LAL method.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of PF4V1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PF4V1 recombinant protein
A DNA sequence encoding the human PF4V1 (NP_002611.1) (Met1-Ser104) was expressed with the Fc region of mouse IgG1 at the C-terminus.
Application Notes for PF4V1 recombinant protein
The recombinant human PF4V1 consists 308 amino acids and predicts a molecular mass of 34.6 kDa.
SDS-PAGE of PF4V1 recombinant protein
NCBI/Uniprot data below describe general gene information for PF4V1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002611.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002620.3
[Other Products]
UniProt Primary Accession #
P10720
[Other Products]
UniProt Secondary Accession #
A1L4S0[Other Products]
UniProt Related Accession #
P10720[Other Products]
Molecular Weight
11,553 Da
NCBI Official Full Name
platelet factor 4 variant
NCBI Official Synonym Full Names
platelet factor 4 variant 1
NCBI Official Symbol
PF4V1 [Similar Products]
NCBI Official Synonym Symbols
PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
[Similar Products]
NCBI Protein Information
platelet factor 4 variant
UniProt Protein Name
Platelet factor 4 variant
UniProt Synonym Protein Names
C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1
Protein Family
Platelet factor
UniProt Gene Name
PF4V1 [Similar Products]
UniProt Synonym Gene Names
CXCL4V1; SCYB4V1 [Similar Products]
NCBI Summary for PF4V1
The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]
UniProt Comments for PF4V1
PF4V1: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Chemokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular space
Molecular Function: chemokine activity; CXCR chemokine receptor binding; heparin binding
Biological Process: G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; positive regulation of leukocyte chemotaxis; regulation of cell proliferation; response to lipopolysaccharide
Research Articles on PF4V1
1. Fibstatin and CXCL4L1 cooperate to inhibit endothelial cell proliferation, migration and tubulogenesis in vitro.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
