Full Product Name
PF4V1 antibody - middle region
Product Gene Name
anti-PF4V1 antibody
[Similar Products]
Product Synonym Gene Name
CXCL4V1; PF4-ALT; PF4A; SCYB4V1; CXCL4L1[Similar Products]
Antibody/Peptide Pairs
PF4V1 peptide (MBS3231137) is used for blocking the activity of PF4V1 antibody (MBS3206173)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: RPRHITSLEV IKAGPHCPTA QLIATLKNGR KICLDLQALL YKKIIKEHLE
3D Structure
ModBase 3D Structure for P10720
Species Reactivity
Human, Pig
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Human: 100%; Pig: 85%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PF4V1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-PF4V1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PF4V1 antibody
This is a rabbit polyclonal antibody against PF4V1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: PF4V1 is the inhibitor of angiogenesis. PF4V1 is the inhibitor of endothelial cell chemotaxis (in vitro).
Product Categories/Family for anti-PF4V1 antibody
Polyclonal; Signal Proteins; Lymphocyte Signaling; Tissue Specific & Cell Marker;
Applications Tested/Suitable for anti-PF4V1 antibody
Western Blot (WB)
Western Blot (WB) of anti-PF4V1 antibody
WB Suggested Anti-PF4V1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: PANC1 cell lysate
NCBI/Uniprot data below describe general gene information for PF4V1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002611
[Other Products]
NCBI GenBank Nucleotide #
NM_002620
[Other Products]
UniProt Primary Accession #
P10720
[Other Products]
UniProt Related Accession #
P10720[Other Products]
NCBI Official Full Name
platelet factor 4 variant
NCBI Official Synonym Full Names
platelet factor 4 variant 1
NCBI Official Symbol
PF4V1 [Similar Products]
NCBI Official Synonym Symbols
PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1
[Similar Products]
NCBI Protein Information
platelet factor 4 variant
UniProt Protein Name
Platelet factor 4 variant
UniProt Synonym Protein Names
C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1
Protein Family
Platelet factor
UniProt Gene Name
PF4V1 [Similar Products]
UniProt Synonym Gene Names
CXCL4V1; SCYB4V1 [Similar Products]
UniProt Entry Name
PF4V_HUMAN
NCBI Summary for PF4V1
The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]
UniProt Comments for PF4V1
PF4V1: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Belongs to the intercrine alpha (chemokine CxC) family.
Protein type: Chemokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q12-q21
Cellular Component: extracellular space
Molecular Function: heparin binding; chemokine activity; CXCR chemokine receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; regulation of cell proliferation
Research Articles on PF4V1
1. Fibstatin and CXCL4L1 cooperate to inhibit endothelial cell proliferation, migration and tubulogenesis in vitro.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
