Full Product Name
MYL2 Rabbit Polyclonal
Product Gene Name
anti-MYL2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Myosin, light chain 2, regulatory, cardiac, slow
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MYL2 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000423.2
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NCBI GenBank Nucleotide #
NM_000432.3
[Other Products]
UniProt Secondary Accession #
Q16123[Other Products]
UniProt Related Accession #
P10916[Other Products]
Molecular Weight
18,789 Da
NCBI Official Full Name
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
NCBI Official Synonym Full Names
myosin light chain 2
NCBI Official Symbol
MYL2 [Similar Products]
NCBI Official Synonym Symbols
MLC2; CMH10; MLC-2s/v
[Similar Products]
NCBI Protein Information
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Synonym Protein Names
Cardiac myosin light chain 2
Protein Family
Myosin regulatory
UniProt Gene Name
MYL2 [Similar Products]
UniProt Synonym Gene Names
MLC-2s/v [Similar Products]
UniProt Entry Name
MLRV_HUMAN
NCBI Summary for MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL2
MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: A band; actin cytoskeleton; cytoskeleton; cytosol; myofibril; myosin complex; sarcomere
Molecular Function: actin monomer binding; calcium ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle
Biological Process: cardiac muscle contraction; cardiac myofibril assembly; heart contraction; heart development; muscle cell fate specification; muscle fiber development; muscle filament sliding; negative regulation of cell growth; post-embryonic development; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 10
Research Articles on MYL2
1. FLNb enhances invasion of cancer cells through phosphorylation of MRLC and FAK.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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