Product Name
FCGR2B, Polyclonal Antibody
Full Product Name
FCGR2B Antibody - middle region
Product Gene Name
anti-FCGR2B antibody
[Similar Products]
Product Synonym Gene Name
CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c[Similar Products]
Antibody/Peptide Pairs
FCGR2B peptide (MBS3247380) is used for blocking the activity of FCGR2B antibody (MBS3222713)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: GNLIPTHTQP SYRFKANNND SGEYTCQTGQ TSLSDPVHLT VLSEWLVLQT
3D Structure
ModBase 3D Structure for P31995
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle terminal region of Human FCGR2C
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-FCGR2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FCGR2B antibody
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-FCGR2B antibody
Polyclonal; Lymphocyte Signaling; Immunology; Disease Related;
Applications Tested/Suitable for anti-FCGR2B antibody
Western Blot (WB)
Western Blot (WB) of anti-FCGR2B antibody
Host: Rabbit
Target Name: FCGR2C
Sample Tissue: Human 293T Whole Cell lysates
Antibody Dilution: 1ug/ml
NCBI/Uniprot data below describe general gene information for FCGR2B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_963857.3
[Other Products]
NCBI GenBank Nucleotide #
NM_201563.5
[Other Products]
UniProt Primary Accession #
P31995
[Other Products]
UniProt Related Accession #
P31995[Other Products]
NCBI Official Full Name
low affinity immunoglobulin gamma Fc region receptor II-c
NCBI Official Synonym Full Names
Fc fragment of IgG receptor IIc (gene/pseudogene)
NCBI Official Symbol
FCGR2C [Similar Products]
NCBI Official Synonym Symbols
CD32; FCG2; CD32C; CDW32; IGFR2; FCRIIC
[Similar Products]
NCBI Protein Information
low affinity immunoglobulin gamma Fc region receptor II-c
UniProt Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-c
UniProt Synonym Protein Names
CDw32; Fc-gamma RII-c
Protein Family
Low affinity immunoglobulin gamma Fc region receptor
UniProt Gene Name
FCGR2C [Similar Products]
UniProt Synonym Gene Names
CD32; FCG2; IGFR2; IgG Fc receptor II-c; Fc-gamma-RIIc; FcRII-c [Similar Products]
UniProt Entry Name
FCG2C_HUMAN
NCBI Summary for FCGR2B
This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants. [provided by RefSeq, Apr 2012]
UniProt Comments for FCGR2B
FCGR2C: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed.
Protein type: Immunoglobulin superfamily; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cytoplasm; plasma membrane; integral to membrane
Molecular Function: protein binding; transmembrane receptor activity; IgG binding
Biological Process: immune response; signal transduction
Disease: Thrombocytopenic Purpura, Autoimmune
Research Articles on FCGR2B
1. When higher-affinity genotypes for FCGR2A, FCGR3A, and FCGR2C were considered together, they were associated with significantly increased tumor shrinkage and prolonged survival in response to HD-IL2... this is the first study to show associations of FCGR genotypes with outcome following HD-IL2 treatment
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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