Product Name
MLNR/GPR38/Motilin Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MLNR/GPR38/Motilin Receptor
Product Synonym Names
Anti-MLNR/GPR38/Motilin Receptor Antibody (C-Terminus) IHC-plus; MLNR; G-protein coupled receptor 38; Motilin receptor; MTLR; MTLR1; G protein-coupled receptor 38; GPR38; Human MLNR/GPR38/Motilin Receptor
Product Gene Name
anti-MLNR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O43193
Species Reactivity
Gorilla, Human
Specificity
Human MLNR. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
0.5 mg/ml (lot specific)
Immunogen Description
Synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human MLNR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Marmoset (81%).
Immunogen Type
Synthetic peptide
Immunogen
MLNR/GPR38/Motilin Receptor antibody was raised against synthetic 16 amino acid peptide from C-terminal cytoplasmic domain of human MLNR. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Marmoset (81%).
Antigen Modification
C-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-MLNR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MLNR antibody
GPR38, also called Motilin Receptor, mediates smooth muscle contraction and controls gastrointestinal motility by binding motilin. The antibiotic erythromycin-A also induces smooth muscle contraction when binding to the motilin receptor. Two variants are produced by alternative splicing.
Product Categories/Family for anti-MLNR antibody
Subfamily:-Motilin">Family: GPCR
Subfamily: Motilin
Applications Tested/Suitable for anti-MLNR antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-MLNR antibody
IHC-P (10 ug/ml)
Immunohistochemistry (IHC) of anti-MLNR antibody
Anti-MLNR antibody IHC of human uterus, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NCBI/Uniprot data below describe general gene information for MLNR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001498.1
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NCBI GenBank Nucleotide #
NM_001507.1
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UniProt Primary Accession #
O43193
[Other Products]
UniProt Related Accession #
O43193[Other Products]
Molecular Weight
42,026 Da
NCBI Official Full Name
motilin receptor
NCBI Official Synonym Full Names
motilin receptor
NCBI Official Symbol
MLNR [Similar Products]
NCBI Official Synonym Symbols
GPR38; MTLR1
[Similar Products]
NCBI Protein Information
motilin receptor; G protein-coupled receptor 38
UniProt Protein Name
Motilin receptor
UniProt Synonym Protein Names
G-protein coupled receptor 38
Protein Family
Motilin receptor
UniProt Gene Name
MLNR [Similar Products]
UniProt Synonym Gene Names
GPR38; MTLR; MTLR1 [Similar Products]
UniProt Entry Name
MTLR_HUMAN
NCBI Summary for MLNR
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
UniProt Comments for MLNR
MLNR: Receptor for motilin. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13q14-q21
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; growth hormone-releasing hormone receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; digestion
Research Articles on MLNR
1. data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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