Full Product Name
KLKB1 (heavy chain,Cleaved-Arg390) Antibody
Product Synonym Names
Coagulation factor XI; Plasma thromboplastin antecedent; PTA; FXI
Product Gene Name
anti-KLKB1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P03952
Specificity
KLKB1 (heavy chain,Cleaved-Arg390) Antibody detects endogenous levels of fragment of activated KLKB1 resulting from cleavage adjacent to Arg390.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Cleaved
Immunogen
The antiserum was produced against synthesized peptide derived from human KLKB1.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KLKB1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-KLKB1 antibody
WB: 1:500~1:1000
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000883.2
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NCBI GenBank Nucleotide #
NM_000892.4
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UniProt Primary Accession #
P03952
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UniProt Secondary Accession #
Q17RE8; Q17RE9; Q4W5C3; A6NH96; B2R8H9[Other Products]
UniProt Related Accession #
P03952[Other Products]
NCBI Official Full Name
plasma kallikrein isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein B1
NCBI Official Symbol
KLKB1 [Similar Products]
NCBI Official Synonym Symbols
PKK; PPK; KLK3; PKKD
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NCBI Protein Information
plasma kallikrein
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein; PKK
Protein Family
Plasma kallikrein
UniProt Gene Name
KLKB1 [Similar Products]
UniProt Synonym Gene Names
KLK3; PKK [Similar Products]
NCBI Summary for KLKB1
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Comments for KLKB1
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Research Articles on KLKB1
1. genetic polymorphism is associated with C1 Inhibitor deficiency angioedema age of onset in European families
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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