Product Name
Sodium / Hydrogen (SLC9A3), Polyclonal Antibody
Full Product Name
Sodium / Hydrogen Exchanger 3 Antibody BIOTIN-Conjugated
Product Synonym Names
MGC126718; MGC126720; NHE3; SLC9A 3; Sodium/hydrogen exchanger 3; Solute carrier family 9 member 3 antibody
Product Gene Name
anti-SLC9A3 antibody
[Similar Products]
Matching Pairs
Antibody: Sodium / Hydrogen (MBS544914)
Positive Control: Sodium / Hydrogen (MBS543268)
Antibody/Peptide Pairs
Sodium / Hydrogen peptide (MBS544486) is used for blocking the activity of Sodium / Hydrogen antibody (MBS544914)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48764
Species Reactivity
Human, Monkey, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.68 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.
Molecular Function
PDZ domain binding; Sodium:proton antiporter activity
Structure
Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels.
Subcellular Location
Apical cell membrane; Multi-pass membrane protein
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-SLC9A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC9A3 antibody
BIOTIN-Conjugated Sodium/Hydrogen Exchanger 3 isoform 1 Antibody
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Applications Tested/Suitable for anti-SLC9A3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-SLC9A3 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for SLC9A3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004165.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004174.3
[Other Products]
UniProt Primary Accession #
P48764
[Other Products]
UniProt Secondary Accession #
Q3MIW3; B7ZKR2; E9PF67[Other Products]
UniProt Related Accession #
P48764[Other Products]
Molecular Weight
91,904 Da[Similar Products]
NCBI Official Full Name
sodium/hydrogen exchanger 3 isoform 1
NCBI Official Synonym Full Names
solute carrier family 9 member A3
NCBI Official Symbol
SLC9A3 [Similar Products]
NCBI Official Synonym Symbols
NHE3; DIAR8; NHE-3
[Similar Products]
NCBI Protein Information
sodium/hydrogen exchanger 3
UniProt Protein Name
Sodium/hydrogen exchanger 3
UniProt Synonym Protein Names
Na(+)/H(+) exchanger 3
Protein Family
Sodium/hydrogen exchanger
UniProt Gene Name
SLC9A3 [Similar Products]
UniProt Synonym Gene Names
NHE-3 [Similar Products]
UniProt Entry Name
SL9A3_HUMAN
NCBI Summary for SLC9A3
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
UniProt Comments for SLC9A3
NHE3: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5p15.3
Cellular Component: apical plasma membrane; brush border; brush border membrane; cell surface; integral to membrane; plasma membrane
Molecular Function: PDZ domain binding; protein binding; sodium:hydrogen antiporter activity
Biological Process: circadian rhythm; ion transport; receptor-mediated endocytosis; regulation of pH; regulation of sodium ion transport; response to glucocorticoid stimulus
Research Articles on SLC9A3
1. Inflammation-induced loss of PDZK1 expression may contribute to the NHE3 dysfunction observed in the inflamed intestine.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
