Full Product Name
Rax Antibody (C-term)
Product Synonym Names
Retinal homeobox protein Rx; Retina and anterior neural fold homeobox protein; RAX; RX
Product Gene Name
anti-RAX antibody
[Similar Products]
Antibody/Peptide Pairs
Rax peptide (MBS9220646) is used for blocking the activity of Rax antibody (MBS9211382)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
315-346
3D Structure
ModBase 3D Structure for Q9Y2V3
Species Reactivity
Human, mouse, rat
Specificity
This Rax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-346 amino acids from the C-terminal region of human Rax.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.38 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-RAX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAX antibody
Rax plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. It binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter.
Product Categories/Family for anti-RAX antibody
Crown Antibodies
Applications Tested/Suitable for anti-RAX antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RAX antibody
WB~~1:1000
Western Blot (WB) of anti-RAX antibody
Rax Antibody (C-term) western blot analysis in Y79 cell line,mouse brain,cerebellum and rat brain,cerebellum tissue lysates (35ug/lane).This demonstrates the Rax antibody detected the Rax protein (arrow).
NCBI/Uniprot data below describe general gene information for RAX. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038463.2
[Other Products]
NCBI GenBank Nucleotide #
NM_013435.2
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UniProt Primary Accession #
Q9Y2V3
[Other Products]
UniProt Secondary Accession #
Q86V11[Other Products]
UniProt Related Accession #
Q9Y2V3[Other Products]
NCBI Official Full Name
retinal homeobox protein Rx
NCBI Official Synonym Full Names
retina and anterior neural fold homeobox
NCBI Official Symbol
RAX [Similar Products]
NCBI Official Synonym Symbols
RX; MCOP3
[Similar Products]
NCBI Protein Information
retinal homeobox protein Rx
UniProt Protein Name
Retinal homeobox protein Rx
UniProt Synonym Protein Names
Retina and anterior neural fold homeobox protein
Protein Family
Retinal homeobox protein
UniProt Gene Name
RAX [Similar Products]
UniProt Synonym Gene Names
RX [Similar Products]
UniProt Entry Name
RX_HUMAN
NCBI Summary for RAX
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.[provided by RefSeq, Oct 2009]
UniProt Comments for RAX
RAX: Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE-1/Ret 1) in the photoreceptor cell-specific arrestin promoter. Defects in RAX are the cause of microphthalmia isolated type 3 (MCOP3). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present. Belongs to the paired homeobox family. Bicoid subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 18q21.32
Cellular Component: nucleus
Biological Process: limb development; hypothalamus development; camera-type eye development; visual perception; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; pattern specification process
Disease: Microphthalmia, Isolated 3
Product References and Citations for anti-RAX antibody
Voronina,V.A., Hum. Mol. Genet. 13 (3), 315-322 (2004)
Mikkola,I., J. Biol. Chem. 276 (6), 4109-4118 (2001)
Mathers,P.H., Cell. Mol. Life Sci. 57 (2), 186-194 (2000)
Research Articles on RAX
1. G mutation (IVS2+3A>G) in RAX.">The three consanguineous Egyptian anophthalmia patients carry a novel homozygous c.543+3A>G mutation (IVS2+3A>G) in RAX.
Precautions
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Disclaimer
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