Product Name
Prekallikrein (Klkb1), Purified Protein
Full Product Name
Recombinant Mouse Prekallikrein
Product Gene Name
Klkb1 purified protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P26262
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
1.0 mg/ml (lot specific)
Source Info
Insect cell culture
Extinction Coefficient
1.33
Buffer
0.004M Sodium Acetate; 0.15M NaCl; pH 5.3
Preparation and Storage
Recommended Storage: At -70 degree C
Minimum Shelf Life: 3 years from delivery
Shipping Condition: Dry ice
Other Notes
Small volumes of Klkb1 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Klkb1 purified protein
Recombinant insect cell derived mouse prekallikrein is a single chain gamma globulin glycoprotein that participates in the early phase of contact activation, kinin formation and fibrinolysis. Prekallikrein is the zymogen precursor of the plasma serine protease kallikrein. Mouse Prekallikrein is >95percent pure by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. Specific activity is determined via complementation in an APTT clotting assay using prekallikrein immuno-deficient human plasma. Custom mutants of recombinant mouse prekallikrein are also available, please contact us for more details.
Product Categories/Family for Klkb1 purified protein
KALLIKREIN/PREKALLIKREIN
NCBI/Uniprot data below describe general gene information for Klkb1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032481.2
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NCBI GenBank Nucleotide #
NM_008455.2
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UniProt Primary Accession #
P26262
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UniProt Secondary Accession #
Q8R0P5[Other Products]
UniProt Related Accession #
P26262[Other Products]
Molecular Weight
81,000 (Approximate)[Similar Products]
NCBI Official Full Name
plasma kallikrein
NCBI Official Synonym Full Names
kallikrein B, plasma 1
NCBI Official Symbol
Klkb1 [Similar Products]
NCBI Official Synonym Symbols
APS; PSA; Kal3; Klk3; Kal-3
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NCBI Protein Information
plasma kallikrein; kininogenin; fletcher factor; kallikrein 3, plasma; plasma prekallikrein; antigen, prostate specific
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikreinCleaved into the following 2 chains:Plasma kallikrein heavy chain; Plasma kallikrein light chain
Protein Family
Plasma kallikrein
UniProt Gene Name
Klkb1 [Similar Products]
UniProt Synonym Gene Names
Klk3; Pk [Similar Products]
UniProt Entry Name
KLKB1_MOUSE
UniProt Comments for Klkb1
KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.34; Protease
Cellular Component: extracellular space; extracellular region
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity
Biological Process: fibrinolysis; hemostasis; positive regulation of fibrinolysis; inflammatory response; blood coagulation; proteolysis; plasminogen activation
Research Articles on Klkb1
1. Plasma kallikrein deletion prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
