Full Product Name
CK-17 Antibody
Product Gene Name
anti-CK-17 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9QWL7
Species Reactivity
Human, Mouse, Rat
Specificity
This antibody is produced by immunizing mouse with a synthetic peptide (KLH-coupled) corresponding to near N-terminal residues of CK17.
Form/Format
In 1*TBS (pH7.4), 0.5%BSA, 25%Glycerol.
Preservative
0.05% Sodium Azide.
Cellular Localization
Cytoplasm
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-CK-17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CK-17 antibody
Cytokeratin 17 may play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Applications Tested/Suitable for anti-CK-17 antibody
Western Blot (WB)
Application Notes for anti-CK-17 antibody
WB: 1:2000
Testing Data of anti-CK-17 antibody
NCBI/Uniprot data below describe general gene information for CK-17. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034793.1
[Other Products]
NCBI GenBank Nucleotide #
NM_010663.3
[Other Products]
UniProt Primary Accession #
Q9QWL7
[Other Products]
UniProt Secondary Accession #
Q61783; A2A4G6[Other Products]
UniProt Related Accession #
Q9QWL7[Other Products]
NCBI Official Full Name
keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
Krt17 [Similar Products]
NCBI Official Synonym Symbols
K17; Krt1-17
[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 17
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
Cytokeratin-17; CK-17; Keratin-17; K17
UniProt Gene Name
Krt17 [Similar Products]
UniProt Synonym Gene Names
Krt1-17; CK-17; K17 [Similar Products]
NCBI Summary for CK-17
The protein encoded by this gene is a member of the type I keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin required for the normal growth of hair follicles and may act in psoriasis as an immunopathogenic autoantigen. [provided by RefSeq, Sep 2015]
UniProt Comments for CK-17
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (PubMed:14714564, PubMed:16702408). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (PubMed:16702408). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (PubMed:16710422). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (PubMed:20871598). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Product References and Citations for anti-CK-17 antibody
1. Fan W., Yoon K. Exp. Dermatol. 12:832-842(2003). 2. Tong X., Coulombe P.A. Genes Dev. 20:1353-1364(2006). 3. Kim S., Wong P., Coulombe P.A. Nature 441:362-365(2006).
Research Articles on CK-17
1. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
