Sox 2, Peptide

Sox 2 (High Mobility Group (HMG) Transcription Factor) Control Peptide (KLH)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 3; NC_000003.11 (181429712..181432224). Location: 3q26.3-q27

Recognizes Sox 2. Species Crossreactivity: Human and rodent.

Highly Purified
Highly purified (HPLC, MS)

Supplied as a liquid in PBS. No preservative added. Conjugated with KLH.

Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.


Small volumes of SOX2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Molecular Biology; MB-Transcription Factors

Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blotting, Immunoprecipitation, Immunohistochemistry and or Immunocytochemistry.

34,310 Da[Similar Products]

SRY (sex determining region Y)-box 2

transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2

Transcription factor SOX-2

SOX2_HUMAN

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206

By similarity. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal

By similarity. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation

By similarity. Ref.5

Subunit structure: Interacts with ZSCAN10

By similarity. Interacts with SOX3 and FGFR1

By similarity.

Subcellular location: Nucleus.

Post-translational modification: Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation

By similarity.

Involvement in disease: Microphthalmia, syndromic, 3 (MCOPS3) [MIM:206900]: A disease characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula. Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4

Biotechnological use: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Ref.5

Sequence similarities: Contains 1 HMG box DNA-binding domain.

Sequence caution: The sequence AAA35997.1 differs from that shown. Reason: Erroneous initiation. The sequence CAA83435.1 differs from that shown. Reason: Erroneous initiation.

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