PEX1, Antibody

Peroxisome biogenesis factor 1; Peroxin-1; Peroxisome biogenesis disorder protein 1

For Research Use Only. Not for use in diagnostic procedures.

PEX1 antibody detects endogenous levels of total PEX1 protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-PEX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC), ELISA (EIA)

IHC: 1:50-1:100
ELISA: 1:10000

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PEX1 antibody.

105,999 Da

peroxisomal biogenesis factor 1

peroxisome biogenesis factor 1

Peroxisome biogenesis factor 1

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.

Portsteffen H., Nat. Genet. 17:449-452(1997). Reuber B.E., Nat. Genet. 17:445-448(1997). Tamura S., Proc. Natl. Acad. Sci. U.S.A. 95:4350-4355(1998).

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