Product Name
Cytokeratin 17 (KRT17), Monoclonal Antibody
Full Product Name
Mouse Anti Human Cytokeratin 17
Product Synonym Names
KRT17 Antibody; Cytokeratin 17, Mouse Anti Human; Keratin 17; PCHC1; 39.1; CK-17; K17; PC2; PC; cytokeratin-17; Keratin 17 Epitope S1; Keratin 17 Epitope S2; Keratin 17 Epitope S4; Keratin; Type I Cytoskeletal 1; keratin-17; Cytokeratin-17; Keratin-17
Product Gene Name
anti-KRT17 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q04695
Purity/Purification
Purified from mouse ascitic fluids by protein-A affinity chromatography
Form/Format
1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.
Ig Subclass
Mouse IgG2a heavy chain and k light chain.
Immunogen
Anti-human KRT17 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human KRT17 protein 1-432 amino acids purified from E Coli.
Preparation and Storage
Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
Stability: 12 months at -20 degree C. 1 month at 4 degree C.
Other Notes
Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT17 antibody
Cytokeratin 17 also known as KRT17 is a type I cytokeratin. KRT17 is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. KRT17 takes part in the formation and maintenance of a variety of skin appendages, particularly in determining shape and orientation of hair. KRT17 also modulates the function of TNF-alpha in the precise context of hair cycling. Moreover, KRT17 regulates protein synthesis and epithelial cell growth all through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway.
Product Categories/Family for anti-KRT17 antibody
MONOCLONAL/POLYCLONAL ANTIBODIES; MISCELLANEOUS ANTIBODIES
Applications Tested/Suitable for anti-KRT17 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-KRT17 antibody
KRT17 antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity.
NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.
NCBI Accession #
CAA79626.1
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UniProt Primary Accession #
Q04695
[Other Products]
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2[Other Products]
UniProt Related Accession #
Q04695[Other Products]
Molecular Weight
48,106 Da
NCBI Official Full Name
cytokeratin 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17 [Similar Products]
NCBI Official Synonym Symbols
PC; K17; PC2; 39.1; CK-17; PCHC1
[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 17
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
UniProt Gene Name
KRT17 [Similar Products]
UniProt Synonym Gene Names
CK-17; K17 [Similar Products]
UniProt Entry Name
K1C17_HUMAN
UniProt Comments for KRT17
K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Molecular Function: MHC class II protein binding; MHC class II receptor activity; protein binding; structural constituent of cytoskeleton
Biological Process: epidermis development; hair follicle morphogenesis; signal transduction
Disease: Pachyonychia Congenita 2; Steatocystoma Multiplex
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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