KCNE1, Polyclonal Antibody

KCNE1; FLJ18426; FLJ38123; FLJ94103; ISK; JLNS; JLNS2; LQT2/5; LQT5; MGC33114; MinK

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-KCNE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Voltage-gated potassium channels play a variety of important roles in human health and disease (1, 2). KCNE1, also known as MinK, belongs to a family of small transmembrane proteins (KCNE1, 2, 3, 4, and KCNE1L) that modulate the activity of several voltage-gated K+ channels (3-5). KCNE1 functions as the modulatory beta-subunit of the pore-forming alpha-subunit KCNQ1, and alters several biophysical properties of KCNQ1 channels (6, 7). Research studies have shown that several inherited mutations in KCNE1 result in long QT syndrome (8-10) and deafness (11).

Western Blot (WB), Immunohistochemistry (IHC)

Western blot analysis of extracts of RAW cell line, using KCNE1 antibody.

Immunohistochemistry of paraffin-embedded human rectal cancer using KCNE1 antibody at dilution of 1:200 (x400 lens)

14,645 Da

potassium channel, voltage gated subfamily E regulatory beta subunit 1

potassium voltage-gated channel subfamily E member 1; IKs producing slow voltage-gated potassium channel subunit beta Mink; cardiac delayed rectifier potassium channel protein; delayed rectifier potassium channel subunit IsK; minimal potassium channel; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; voltage gated potassiun channel accessory subunit

KCNE1 protein

Q6FHJ6_HUMAN

The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: voltage-gated potassium channel complex; cell surface; lysosome; apical plasma membrane; plasma membrane; Z disc

Molecular Function: voltage-gated potassium channel activity; protein binding; potassium channel regulator activity; telethonin binding; delayed rectifier potassium channel activity

Biological Process: protein amino acid O-linked glycosylation; sensory perception of sound; protein amino acid N-linked glycosylation

Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5

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