Product Name
CRBN, Blocking Peptide
Full Product Name
CRBN Peptide
Product Synonym Names
Cereblon; AD-006; DKFZp781K0715; MGC27358; MRT2A; cereblon
Product Gene Name
CRBN blocking peptide
[Similar Products]
CRBN peptide (MBS153857) is used for blocking the activity of CRBN antibody (MBS153555)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SW2
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
16 amino acid peptide near the carboxy terminus of human CRBN.
Preparation and Storage
Store CRBN peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of CRBN blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for CRBN blocking peptide
Blocking (BL)
Application Notes for CRBN blocking peptide
CRBN peptide is used for blocking the activity of CRBN antibody.
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_057386
[Other Products]
NCBI GenBank Nucleotide #
NM_016302.3
[Other Products]
UniProt Primary Accession #
Q96SW2
[Other Products]
UniProt Secondary Accession #
Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6[Other Products]
UniProt Related Accession #
Q96SW2[Other Products]
Molecular Weight
50,475 Da
NCBI Official Full Name
protein cereblon isoform 1
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
CRBN [Similar Products]
NCBI Official Synonym Symbols
MRT2; MRT2A
[Similar Products]
NCBI Protein Information
protein cereblon; protein x 0001
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
CRBN [Similar Products]
UniProt Entry Name
CRBN_HUMAN
NCBI Summary for CRBN
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for CRBN
CRBN: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Defects in CRBN are the cause of mental retardation autosomal recessive type 2A (MRT2A). MRT2A patients display mild mental retardation with a standard IQ ranged from 50 to 70. IQ scores are lower in males than females. Developmental milestones are mildly delayed. There are no dysmorphic or autistic features. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the CRBN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p26.2
Cellular Component: membrane; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; metal ion binding; ATP-dependent peptidase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; negative regulation of protein homooligomerization
Disease: Mental Retardation, Autosomal Recessive 2
Research Articles on CRBN
1. The study presents the crystal structure of human CRBN bound to DDB1 and the drug lenalidomide.
Precautions
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Disclaimer
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