Full Product Name
CRBN Antibody
Product Gene Name
anti-CRBN antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SW2
Other Notes
Small volumes of anti-CRBN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CRBN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166953.1
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NCBI GenBank Nucleotide #
NM_001173482.1
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UniProt Primary Accession #
Q96SW2
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UniProt Secondary Accession #
Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6[Other Products]
UniProt Related Accession #
Q96SW2[Other Products]
Molecular Weight
50,475 Da
NCBI Official Full Name
protein cereblon isoform 2
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
CRBN [Similar Products]
NCBI Official Synonym Symbols
MRT2; MRT2A
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NCBI Protein Information
protein cereblon
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
CRBN [Similar Products]
NCBI Summary for CRBN
This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for CRBN
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
Research Articles on CRBN
1. we identify Rabex-5 as a Immunomodulatory drugs (IMiDs) target molecule that functions to restrain TLR activated auto-immune promoting pathways. We propose that release of Rabex-5 from complex with Cereblon enables the suppression of immune responses, contributing to the antiinflammatory properties of IMiDs.
Precautions
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Disclaimer
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