Full Product Name
CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358)
Product Synonym Names
Anti -CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358)
Product Gene Name
anti-crbn antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS ALLPTIPDTE DEISPDKVIL CL
Chromosome Location
Chromosome: 6; NC_007117.5 (40387662..40397691, complement). Location: chromosome: 6
3D Structure
ModBase 3D Structure for Q68EH9
Specificity
Recognizes human CRBN.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human CRBN, aa1-442 (NP_057386.2).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-crbn antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-crbn antibody
Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
Product Categories/Family for anti-crbn antibody
Antibodies; Abs to Neuroscience
Applications Tested/Suitable for anti-crbn antibody
Western Blot (WB)
Application Notes for anti-crbn antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for crbn. It may not necessarily be applicable to this product.
NCBI Accession #
AAI64733.1
[Other Products]
UniProt Primary Accession #
Q68EH9
[Other Products]
UniProt Related Accession #
Q68EH9[Other Products]
Molecular Weight
49,095 Da[Similar Products]
NCBI Official Full Name
Crbn protein
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
crbn [Similar Products]
NCBI Official Synonym Symbols
zgc:92404
[Similar Products]
NCBI Protein Information
protein cereblon; zcrbn
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
crbn [Similar Products]
UniProt Synonym Gene Names
zcrbn [Similar Products]
UniProt Entry Name
CRBN_DANRE
UniProt Comments for crbn
Function: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. May also be involved in memory and learning. Ref.2
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Component of a DCX (DDB1-CUL4-X-box) protein ligase complex
By similarity.
Subcellular location: Cytoplasm
By similarity. Nucleus
By similarity.
Tissue specificity: Highly expressed in brain, head, vasculature otic vesicles and developing pectoral fins. Ref.2
Disruption phenotype: Specific defects in fin and otic vesicle development. Ref.2
Miscellaneous: Specifically binds thalidomide. Thalidomide teratogenic activity may be a consequence of crbn-binding. Overexpression of a mutant protein abolishing thalidomide-binding does not affect otic vesicle size (Ref.2).
Sequence similarities: Belongs to the CRBN family.Contains 1 Lon domain.
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Disclaimer
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