Product Name
Protein cereblon (crbn), Recombinant Protein
Full Product Name
Recombinant Xenopus tropicalis Protein cereblon (crbn)
Product Gene Name
crbn recombinant protein
[Similar Products]
Product Synonym Gene Name
crbn[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-447aa, full length protein
Sequence
MADDEGEEDP GINNMGNLLQ VISSESEEED EMELEDAKTA DSESPNIINF DTSLPTSHAY LGVDMEEFHG RTLHDDDSCQ QIPVLPHVQV MLIPGQTLPL HLSRPQEVSM VRGLIQRDRT FAVLAYSDGL QREAHFGTTA EIYAYREEHE FGIETVKVKA IGRQRFQVLE TRTQADGIQV ARVQILPERV LPCPMTSLQL DSQSRHLLFP TNKPVSGRSP QSKCQWLHKY RRRKFLGASL TSWPSWLYAL YDADSLMERV KLQLHEWDEN LRDDSLPANP IDFSYRVAAC LPIDDALRIQ LLQIGNAIQR LRCELDIMSK CTSLCCKHCP DTEITTKNEI FSLSLCGPMA AYVNPHGYVH ETLTVYKAFN LSLVGRPSTE NSWFPGFAWT IAQCRVCGSH MGWKFTAVRK DLSPQKFWGL TRSALQPRIP EPDEGEMGHD HSPILCL
3D Structure
ModBase 3D Structure for Q640S2
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of crbn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for crbn. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001008192.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001008191.1
[Other Products]
UniProt Primary Accession #
Q640S2
[Other Products]
UniProt Related Accession #
Q640S2[Other Products]
Molecular Weight
50,667 Da
NCBI Official Full Name
protein cereblon
NCBI Official Synonym Full Names
cereblon
NCBI Official Symbol
crbn [Similar Products]
NCBI Official Synonym Symbols
mrt2a
[Similar Products]
NCBI Protein Information
protein cereblon
UniProt Protein Name
Protein cereblon
Protein Family
Protein cereblon
UniProt Gene Name
crbn [Similar Products]
UniProt Comments for crbn
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
