Full Product Name
CDK5RAP2 Antibody
Product Synonym Names
C5P2; CDK5 activator-binding protein C48; CK5P2; KIAA1633; CDK5 regulatory subunit associated protein 2
Product Gene Name
anti-CDK5RAP2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96SN8
Specificity
CDK5RAP2 antibody detects endogenous levels of total CDK5RAP2 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from N-terminal of human CDK5RAP2.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CDK5RAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CDK5RAP2 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CDK5RAP2 antibody
IHC: 1:50-1:100
ELISA: 1:20000
Immunohistochemistry (IHC) of anti-CDK5RAP2 antibody
Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using CDK5RAP2 antibody.
NCBI/Uniprot data below describe general gene information for CDK5RAP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001011649.1
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NCBI GenBank Nucleotide #
NM_001011649.2
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UniProt Primary Accession #
Q96SN8
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UniProt Secondary Accession #
Q5JV18; Q7Z3L4; Q7Z3U1; Q7Z7I6; Q9BSW0; Q9H6J6; Q9HCD9; Q9NV90; Q9UIW9[Other Products]
UniProt Related Accession #
Q96SN8[Other Products]
Molecular Weight
206,323 Da
NCBI Official Full Name
CDK5 regulatory subunit-associated protein 2 isoform b
NCBI Official Synonym Full Names
CDK5 regulatory subunit associated protein 2
NCBI Official Symbol
CDK5RAP2 [Similar Products]
NCBI Official Synonym Symbols
C48; MCPH3; Cep215
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NCBI Protein Information
CDK5 regulatory subunit-associated protein 2
UniProt Protein Name
CDK5 regulatory subunit-associated protein 2
UniProt Synonym Protein Names
CDK5 activator-binding protein C48; Centrosome-associated protein 215
Protein Family
CDK5 regulatory subunit-associated protein
UniProt Gene Name
CDK5RAP2 [Similar Products]
UniProt Synonym Gene Names
CEP215; KIAA1633 [Similar Products]
NCBI Summary for CDK5RAP2
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for CDK5RAP2
Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis ().
Product References and Citations for anti-CDK5RAP2 antibody
Nagase T., DNA Res. 7:273-281(2000). Humphray S.J., Nature 429:369-374(2004). Ota T., Nat. Genet. 36:40-45(2004).
Research Articles on CDK5RAP2
1. A frameshift mutation in CDK5RAP2 gene is associated with primary microcephaly with speech impairment and sparse eyebrows in a consanguineous Pakistani family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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