Product Name
ASIP, Blocking Peptide
Full Product Name
ASIP Peptide - middle region
Product Gene Name
ASIP blocking peptide
[Similar Products]
Product Synonym Gene Name
ASP; AGSW; AGTI; AGTIL; SHEP9[Similar Products]
ASIP peptide (MBS3246346) is used for blocking the activity of ASIP antibody (MBS3221613)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: CFFTANSHLP PEEKLRDDRS LRSNSSVNLL DVPSVSIVAL NKKSKQIGRK
3D Structure
ModBase 3D Structure for P42127
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of ASIP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ASIP blocking peptide
This is a synthetic peptide designed for use in combination with anti- ASIP Antibody, made
Target Description: In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include *****-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
Product Categories/Family for ASIP blocking peptide
Peptide
NCBI/Uniprot data below describe general gene information for ASIP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001663.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001672.2
[Other Products]
UniProt Primary Accession #
P42127
[Other Products]
UniProt Related Accession #
P42127[Other Products]
NCBI Official Full Name
agouti-signaling protein
NCBI Official Synonym Full Names
agouti signaling protein
NCBI Official Symbol
ASIP [Similar Products]
NCBI Official Synonym Symbols
ASP; AGSW; AGTI; AGTIL; SHEP9
[Similar Products]
NCBI Protein Information
agouti-signaling protein
UniProt Protein Name
Agouti-signaling protein
UniProt Synonym Protein Names
Agouti switch protein
Protein Family
Agouti-signaling protein
UniProt Gene Name
ASIP [Similar Products]
UniProt Synonym Gene Names
AGTI; AGTIL; ASP; ASP [Similar Products]
UniProt Entry Name
ASIP_HUMAN
NCBI Summary for ASIP
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include *****-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for ASIP
ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q11.2-q12
Cellular Component: extracellular space
Molecular Function: type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; receptor binding
Biological Process: melanin biosynthetic process; generation of precursor metabolites and energy; regulation of molecular function, epigenetic; hormone-mediated signaling; cell-cell signaling; melanosome organization and biogenesis; ***** feeding behavior; signal transduction; melanosome transport
Disease: Skin/hair/eye Pigmentation, Variation In, 9
Research Articles on ASIP
1. ASIP expression is significantly downregulated in human masticatory mucosa during wound healing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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