Full Product Name
ASIP Antibody, Biotin conjugated
Product Synonym Names
Agouti-signaling proteinASP; Agouti switch protein; ASIP; AGTI; AGTIL; ASP
Product Gene Name
anti-ASIP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P42127
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant human Agouti-signaling protein
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18626 / sc-18627
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ASIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASIP antibody
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Applications Tested/Suitable for anti-ASIP antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ASIP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001663.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001672.2
[Other Products]
UniProt Primary Accession #
P42127
[Other Products]
UniProt Secondary Accession #
Q3SXL2[Other Products]
UniProt Related Accession #
P42127[Other Products]
Molecular Weight
14,515 Da
NCBI Official Full Name
agouti-signaling protein
NCBI Official Synonym Full Names
agouti signaling protein
NCBI Official Symbol
ASIP [Similar Products]
NCBI Official Synonym Symbols
ASP; AGSW; AGTI; AGTIL; SHEP9
[Similar Products]
NCBI Protein Information
agouti-signaling protein
UniProt Protein Name
Agouti-signaling protein
UniProt Synonym Protein Names
Agouti switch protein
Protein Family
Agouti-signaling protein
UniProt Gene Name
ASIP [Similar Products]
UniProt Synonym Gene Names
AGTI; AGTIL; ASP; ASP [Similar Products]
UniProt Entry Name
ASIP_HUMAN
NCBI Summary for ASIP
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include *****-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
UniProt Comments for ASIP
ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 20q11.2-q12
Cellular Component: extracellular space
Molecular Function: receptor binding
Biological Process: cell-cell signaling; signal transduction
Disease: Skin/hair/eye Pigmentation, Variation In, 9
Research Articles on ASIP
1. Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.
Precautions
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Disclaimer
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