Product Name
Phospho-CACNB2, Polyclonal Antibody
Full Product Name
Phospho CACNB2 Antibody BIOTIN-Conjugated
Product Synonym Names
AW060387; Ca(V) beta 2; CAB2; CAVB2; Cavbeta2; Cchb2; Lambert Eaton Myasthenic syndrome antigen; MYSB antibody
Product Gene Name
anti-CACNB2 antibody
[Similar Products]
Matching Pairs
Antibody: Phospho-CACNB2 (MBS542598)
Positive Control: Phospho-CACNB2 (MBS543051)
Antibody/Peptide Pairs
Phospho-CACNB2 peptide (MBS544140) is used for blocking the activity of Phospho-CACNB2 antibody (MBS542598)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8VGC3
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.6 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 560-610 on rat CCb2 protein.
Expression
Heart and brain. Lower expression in lung.
Modification
Phosphorylated
Molecular Function
Calcium; Transport; Ion transport
Structure
L-type channel is composed of four subunits: alpha-1, alpha-2, beta and gamma.
Subcellular Location
Cell membrane; Sacrolemma; Peripheral membrane protein, Cytoplasmic side
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CACNB2 antibody
BIOTIN-Conjugated Voltage dependent L-type calcium channel subunit beta-2 Antibody
The beta subunit of voltage-dependent calcium channel which contributes to calcium channel function by increasing peak calcium current, shifting the voltage dependencies fo activation and inactivation, modulating G-protein inhibition and controllin the alpha-1 subunit membrane targeting.
Applications Tested/Suitable for anti-CACNB2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CACNB2 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for CACNB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_446303
[Other Products]
NCBI GenBank Nucleotide #
NM_053851.1
[Other Products]
UniProt Primary Accession #
Q8VGC3
[Other Products]
UniProt Secondary Accession #
Q811Q6; Q811Q7; Q91ZJ8; Q9QUU7[Other Products]
UniProt Related Accession #
Q8VGC3[Other Products]
Molecular Weight
68,066 Da
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-2
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit beta 2
NCBI Official Symbol
Cacnb2 [Similar Products]
NCBI Official Synonym Symbols
Cacnlb2
[Similar Products]
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-2
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-2
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 2
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
Cacnb2 [Similar Products]
UniProt Synonym Gene Names
Cacnlb2; CAB2 [Similar Products]
UniProt Entry Name
CACB2_RAT
NCBI Summary for CACNB2
auxillary subunit of the L-type Ca(2+) channel [RGD, Feb 2006]
UniProt Comments for CACNB2
CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium
Cellular Component: sarcolemma; voltage-gated calcium channel complex
Molecular Function: actin filament binding; calcium channel regulator activity; high voltage-gated calcium channel activity; phosphoprotein binding; protein binding; protein domain specific binding; protein kinase binding; voltage-gated calcium channel activity
Biological Process: calcium ion transport; neuromuscular junction development; positive regulation of calcium ion transport; synaptic transmission; visual perception
Research Articles on CACNB2
1. these findings provide evidence for a new role of Homer1 supporting the regulation of Cav1.2 channels by STIM1.
Precautions
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Disclaimer
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