HYAL1, Polyclonal Antibody

Hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung carcinoma protein 1; LuCa-1; HYAL1; LUCA1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This HYAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human HYAL1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-HYAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a lysosomal hyaluronidase.
Hyaluronidases intracellularly degrade hyaluronan, one of the major
glycosaminoglycans of the extracellular matrix. Hyaluronan is
thought to be involved in cell proliferation, migration and
differentiation. This enzyme is active at an acidic pH and is the
major hyaluronidase in plasma. Mutations in this gene are
associated with mucopolysaccharidosis type IX, or hyaluronidase
deficiency. The gene is one of several related genes in a region of
chromosome 3p21.3 associated with tumor suppression. Multiple
transcript variants encoding different isoforms have been found for
this gene.

Cancer; Signal Transduction

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

WB~~1:1000

HYAL1 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the HYAL1 antibody detected the HYAL1 protein (arrow).

HYAL1 Antibody (C-term) (MBS9203612)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HYAL1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

48368

hyaluronoglucosaminidase 1

hyaluronidase-1

Hyaluronidase-1

LUCA1; Hyal-1; LuCa-1  [Similar Products]

HYAL1_HUMAN

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Secreted; Secreted, signal peptide; Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.35

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: lysosomal lumen; extracellular space; lysosome; cytoplasm; cytoplasmic vesicle

Molecular Function: viral receptor activity; hyaluronan synthase activity; transcription factor binding; hyalurononglucosaminidase activity

Biological Process: positive regulation of cell adhesion; glycosaminoglycan metabolic process; response to virus; pathogenesis; positive regulation of cell growth; hyaluronan catabolic process; chondroitin sulfate metabolic process; response to antibiotic; positive regulation of angiogenesis; response to reactive oxygen species; hyaluronan biosynthetic process; cartilage development; chondroitin sulfate catabolic process; carbohydrate metabolic process; negative regulation of cell growth; inflammatory response; positive regulation of growth; hyaluronan metabolic process; positive regulation of epithelial cell proliferation

Disease: Mucopolysaccharidosis, Type Ix

Lanktree, M.B., et al. Blood 116(12):2160-2163(2010)
Gasingirwa, M.C., et al. Biochem. J. 430(2):305-313(2010)
Tzuman, Y.C., et al. Neoplasia 12(1):51-60(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Wang, X.Y., et al. Chin. Med. J. 122(11):1300-1304(2009)

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