CACNB2, Polyclonal Antibody

Voltage-dependent L-type calcium channel subunit beta-2; CAB2; Calcium channel voltage-dependent subunit beta 2; Lambert-Eaton myasthenic syndrome antigen B; MYSB; CACNB2; CACNLB2; MYSB

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This CACNB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the Central region of human CACNB2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.4 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CACNB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a subunit of a voltage-dependent calcium
channel protein which is a member of the voltage-gated calcium
channel superfamily. The gene product was originally identified as
an antigen target in Lambert-Eaton myasthenic syndrome which is an
autoimmune disorder. Mutations in this gene are associated with
Brugada symdrome. Alternatively spliced variants have been
identified for this gene.

Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

CACNB2 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CACNB2 antibody detected the CACNB2 protein (arrow).

73581

calcium channel, voltage-dependent, beta 2 subunit

voltage-dependent L-type calcium channel subunit beta-2

Voltage-dependent L-type calcium channel subunit beta-2

CACNLB2; MYSB; CAB2; MYSB  [Similar Products]

CACB2_HUMAN

This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013]

CACNB2: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRGDA4). A heart disease characterized by the association of Brugada syndrome with shortened QT intervals. Brugada syndrome is a tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the calcium channel beta subunit family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: integral to plasma membrane; voltage-gated calcium channel complex; sarcolemma

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium channel activity; high voltage-gated calcium channel activity

Biological Process: synaptic transmission; axon guidance; visual perception; transport; positive regulation of calcium ion transport; neuromuscular junction development

Disease: Brugada Syndrome 4

Burashnikov, E., et al. Heart Rhythm (2010) In press :
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Takeuchi, F., et al. Circulation 121(21):2302-2309(2010)
Hong, K.W., et al. J. Hum. Genet. 55(6):336-341(2010)
Lee, M.T., et al. Mol. Psychiatry (2010) In press :

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