Full Product Name
CABP4, CT (CABP4, Calcium-binding protein 4)
Product Synonym Names
Anti -CABP4, CT (CABP4, Calcium-binding protein 4)
Product Gene Name
anti-CABP4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (67219886..67229245). Location: 11q13.2
3D Structure
ModBase 3D Structure for P57796
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
CABP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-203 amino acids from the C-terminal region of human CABP4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-CABP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CABP4 antibody
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B.
Product Categories/Family for anti-CABP4 antibody
Antibodies; Abs to Calcium Binding Proteins
Applications Tested/Suitable for anti-CABP4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CABP4 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for CABP4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_660201.1
[Other Products]
NCBI GenBank Nucleotide #
NM_145200.3
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UniProt Primary Accession #
P57796
[Other Products]
UniProt Secondary Accession #
Q8N4Z2; Q8WWY5[Other Products]
UniProt Related Accession #
P57796[Other Products]
Molecular Weight
30,433 Da[Similar Products]
NCBI Official Full Name
calcium-binding protein 4
NCBI Official Synonym Full Names
calcium binding protein 4
NCBI Official Symbol
CABP4 [Similar Products]
NCBI Official Synonym Symbols
CSNB2B
[Similar Products]
NCBI Protein Information
calcium-binding protein 4
UniProt Protein Name
Calcium-binding protein 4
Protein Family
Calcium-binding protein
UniProt Gene Name
CABP4 [Similar Products]
UniProt Synonym Gene Names
CaBP4 [Similar Products]
UniProt Entry Name
CABP4_HUMAN
NCBI Summary for CABP4
This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. [provided by RefSeq, Mar 2010]
UniProt Comments for CABP4
Function: Involved in normal synaptic function through regulation of Ca2+ influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages
By similarity.
Subunit structure: Interacts with CACNA1F and CACNA1D (via IQ domain) in a calcium independent manner
By similarity. Interacts (via N-terminus) with UNC119
By similarity.
Subcellular location: Cytoplasm. Note: Found in rod spherules and cone pedicles of the presynapses from both types of photoreceptors
By similarity. Ref.5
Tissue specificity: Expressed in retina and in the inner hair cells (IHC) of the cochlea.
Post-translational modification: Phosphorylated. Phosphorylation levels change with the light conditions and regulate the activity
By similarity.
Involvement in disease: Night blindness, congenital stationary, 2B (CSNB2B) [MIM:610427]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities: Contains 4 EF-hand domains.
Research Articles on CABP4
1. Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).
Precautions
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Disclaimer
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