Full Product Name
DHCR24 Antibody
Product Gene Name
anti-DHCR24 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15392
Other Notes
Small volumes of anti-DHCR24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DHCR24. It may not necessarily be applicable to this product.
NCBI Accession #
NP_055577.1
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NCBI GenBank Nucleotide #
NM_014762.3
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UniProt Primary Accession #
Q15392
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UniProt Secondary Accession #
Q9HBA8; B7Z817; D3DQ51[Other Products]
UniProt Related Accession #
Q15392[Other Products]
Molecular Weight
54,750 Da
NCBI Official Full Name
delta(24)-sterol reductase
NCBI Official Synonym Full Names
24-dehydrocholesterol reductase
NCBI Official Symbol
DHCR24 [Similar Products]
NCBI Official Synonym Symbols
DCE; SELADIN1; Nbla03646; seladin-1
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NCBI Protein Information
delta(24)-sterol reductase
UniProt Protein Name
Delta(24)-sterol reductase
UniProt Synonym Protein Names
24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase; Diminuto/dwarf1 homolog; Seladin-1
Protein Family
Delta(24)-sterol reductase
UniProt Gene Name
DHCR24 [Similar Products]
UniProt Synonym Gene Names
KIAA0018 [Similar Products]
NCBI Summary for DHCR24
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
UniProt Comments for DHCR24
Catalyzes the reduction of the Delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
Research Articles on DHCR24
1. the expanding database of post-translational modifications will be a valuable resource for mapping the topology of membrane-associated proteins, such as DHCR24, that is, flagging cytosolic residues accessible to modifying enzymes such as kinases and ubiquitin ligases.
Precautions
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Disclaimer
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