TLR3, Blocking Peptide

CD283; CD283 antigen; IIAE2; TLR 3; Toll Like Receptor 3 antibody

For Research Use Only. Not for use in diagnostic procedures.

Antigenic Blocking Peptide

Quantity: 250 ug; Volume: 100 ul (lot specific)

-20 degree C for long term storage

Small volumes of TLR3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antigenic Blocking Peptide Toll-like receptor 3
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection.

Immunocompeition, Immunodepletion

Immunohistochemistry: 1:100
Western Blot: 1:500

72,937 Da

toll like receptor 3

toll-like receptor 3

Toll-like receptor 3

TLR3_HUMAN

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: cell surface; cytoplasm; early endosome; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to plasma membrane; intracellular; lysosomal membrane; membrane

Molecular Function: double-stranded RNA binding; identical protein binding; protein binding; receptor activity; transmembrane receptor activity

Biological Process: activation of NF-kappaB transcription factor; activation of NF-kappaB-inducing kinase; defense response to bacterium; defense response to virus; detection of virus; hyperosmotic response; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; inflammatory response; innate immune response; male gonad development; microglial cell activation during immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; negative regulation of osteoclast differentiation; positive regulation of apoptosis; positive regulation of chemokine biosynthetic process; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of dendritic cell cytokine production; response to exogenous dsRNA; signal transduction; toll-like receptor 3 signaling pathway; toll-like receptor signaling pathway

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

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