Product Name
Short-chain specific acyl-CoA dehydrogenase (ACADS), Polyclonal Antibody
Popular Item
Full Product Name
Rabbit anti-human Short-chain specific acyl-CoA dehydrogenase, mitochondrial polyclonal Antibody(ACADS)
Product Synonym Names
Short-chain specific acyl-CoA dehydrogenase; mitochondrial; SCAD; Butyryl-CoA dehydrogenase; ACADS
Product Gene Name
anti-ACADS antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P16219
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Immunogen
Recombinant human Short-chain specific acyl-CoA dehydrogenase, mitochondrial protein(1-260aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107371 / sc-135342
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ACADS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACADS antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ACADS antibody
Recommended dilution: WB:1:500-1000
IHC:1:20-1:200
Western Blot (WB) of anti-ACADS antibody
All lanes: Short-chain specific acyl-CoA dehydrogenase, mitochondrial antibody at 7ug/ml
Lane 1:293T whole cell lysate
Lane 2:HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 44kDa
Observed band size: 44kDa
Immunohistochemistry (IHC) of anti-ACADS antibody
Immunohistochemistry of paraffin-embedded human liver using MBS968811 at dilution 1:100
Immunohistochemistry (IHC) of anti-ACADS antibody
Immunohistochemistry of paraffin-embedded human pancreas using MBS968811 at dilution 1:100
NCBI/Uniprot data below describe general gene information for ACADS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000008.1
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NCBI GenBank Nucleotide #
NM_000017.3
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UniProt Primary Accession #
P16219
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UniProt Secondary Accession #
P78331[Other Products]
UniProt Related Accession #
P16219[Other Products]
Molecular Weight
44,297 Da
NCBI Official Full Name
short-chain specific acyl-CoA dehydrogenase, mitochondrial isoform 1
NCBI Official Synonym Full Names
acyl-CoA dehydrogenase, C-2 to C-3 short chain
NCBI Official Symbol
ACADS [Similar Products]
NCBI Official Synonym Symbols
SCAD; ACAD3
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NCBI Protein Information
short-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Synonym Protein Names
Butyryl-CoA dehydrogenase
Protein Family
Short-chain specific acyl-CoA dehydrogenase
UniProt Gene Name
ACADS [Similar Products]
UniProt Synonym Gene Names
SCAD [Similar Products]
UniProt Entry Name
ACADS_HUMAN
NCBI Summary for ACADS
This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with short-chain acyl-CoA dehydrogenase (SCAD) deficiency. Alternative splicing results in two variants which encode different isoforms. [provided by RefSeq, Oct 2014]
UniProt Comments for ACADS
ACADS: Defects in ACADS are the cause of acyl-CoA dehydrogenase short-chain deficiency (ACADSD). It is an autosomal recessive disorder resulting in acute acidosis and muscle weakness in infants, and a form of lipid-storage myopathy in *****s. Belongs to the acyl-CoA dehydrogenase family.
Protein type: EC 1.3.8.1; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; Carbohydrate Metabolism - butanoate; Lipid Metabolism - fatty acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: mitochondrial matrix; mitochondrion; nucleus
Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; electron carrier activity; FAD binding
Biological Process: butyrate catabolic process; cellular lipid metabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis; protein homotetramerization; response to glucocorticoid stimulus; response to starvation
Disease: Acyl-coa Dehydrogenase, Short-chain, Deficiency Of
Research Articles on ACADS
1. T in ACADS compared to controls and they belonged to various pathways, such as the antioxidant system and amino acid metabolism.">Thirteen proteins had significant alteration in protein levels in patients carrying variation c.319C>T in ACADS compared to controls and they belonged to various pathways, such as the antioxidant system and amino acid metabolism.
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