WNT10A, Polyclonal Antibody

Anti-WNT10A Antibody (Internal) IHC-plus; WNT10A; SSPS; STHAG4; OODD; Protein Wnt-10a; Human WNT10A

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human WNT10A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-WNT10A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Wnts are important signaling molecules involved in normal developmental processes as well as some forms of cancer. WNT10A expression has been documented in many cancers, include those of the stomach, colon, breast, bone marrow, esophagus, and blood.

Family: WNT

Immunohistochemistry (IHC - Paraffin)

IHC-P (5 ug/ml)

Anti-WNT10A antibody IHC of human pancreatic islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Human Melanoma (Lymph Node): Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Stomach: Formalin-Fixed, Paraffin-Embedded (FFPE)

46,444 Da

wingless-type MMTV integration site family, member 10A

protein Wnt-10a

Protein Wnt-10a

WN10A_HUMAN

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

WNT10A: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Defects in WNT10A are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Most patients carrying WNT10A mutations present with sweating anomalies. However, comparison with EDA cases harboring mutations in the ectodysplasin pathway identifies some phenotypic differences. Dermatological features (anomalies of hair and sweat glands) are less severe in patients carrying WNT10A mutations and facial dysmorphism can be absent. The dental phenotype consists in microdontia, whereas teeth agenesis is more frequent in patients carrying mutations in the ectodysplasin pathway. Defects in WNT10A are a cause of odonto-onycho-dermal dysplasia (OODD). OODD is a rare autosomal recessive ectodermal dysplasia in which the presenting phenotype is dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin. Defects in WNT10A are a cause of Schopf-Schulz-Passarge syndrome (SSPS). SSPS is rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in *****hood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms. Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: frizzled binding

Biological Process: skin development; odontogenesis; neuron differentiation; tongue development; cell fate commitment; Wnt receptor signaling pathway; hair follicle morphogenesis; hair follicle development; epidermis morphogenesis; sebaceous gland development; neural crest cell differentiation; regulation of odontogenesis of dentine-containing teeth

Disease: Schopf-schulz-passarge Syndrome; Tooth Agenesis, Selective, 4; Odontoonychodermal Dysplasia

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