PEX1, Polyclonal Antibody

Anti -PEX1, ID (PEX1, Peroxisome biogenesis factor 1, Peroxin-1, Peroxisome biogenesis disorder protein 1)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_000007.13 (92116337..92157845, complement). Location: 7q21.2

Polyclonal

IgG

Rabbit

Human

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-PEX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.

Antibodies; Abs to Obesity Proteins

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

142,867 Da[Similar Products]

peroxisomal biogenesis factor 1

peroxisome biogenesis factor 1; peroxin-1; Zellweger syndrome; peroxisome biogenesis disorder protein 1

Peroxisome biogenesis factor 1

PEX1_HUMAN

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

PEX1: Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Belongs to the AAA ATPase family. Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6.

Protein type: Hydrolase

Chromosomal Location of Human Ortholog: 7q21.2

Cellular Component: peroxisomal membrane; intracellular membrane-bound organelle; cytoplasm; peroxisome; cytosol

Molecular Function: protein C-terminus binding; protein binding; protein complex binding; ATPase activity, coupled; ATP binding

Biological Process: peroxisome organization and biogenesis; metabolic process; protein targeting to peroxisome; microtubule-based peroxisome localization; protein import into peroxisome matrix

Disease: Peroxisome Biogenesis Disorder 1a (zellweger); Peroxisome Biogenesis Disorder 1b

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