Full Product Name
ASPA Antibody
Product Synonym Names
ACY2; ASP
Product Gene Name
anti-ASPA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6FH48
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of ASPA
Calculated Molecular Weight: 313aa; 36kd
Observed Molecular Weight: 36kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109208 / sc-109209 / sc-109212 / sc-98734
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ASPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ASPA antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ASPA antibody
WB: 1:200-1:2000
IHC: 1:50-1:200
Testing Data of anti-ASPA antibody
NCBI/Uniprot data below describe general gene information for ASPA. It may not necessarily be applicable to this product.
NCBI Accession #
CAG46706.1
[Other Products]
UniProt Primary Accession #
Q6FH48
[Other Products]
UniProt Related Accession #
P45381[Other Products]
Molecular Weight
35,735 Da
NCBI Official Full Name
ASPA, partial
NCBI Official Synonym Full Names
aspartoacylase
NCBI Official Symbol
ASPA [Similar Products]
NCBI Official Synonym Symbols
ASP; ACY2
[Similar Products]
NCBI Protein Information
aspartoacylase; ACY-2; aminoacylase 2; aminoacylase-2
UniProt Protein Name
ASPA protein
UniProt Synonym Protein Names
ASPA protein
Protein Family
Aspartocin
UniProt Gene Name
ASPA [Similar Products]
UniProt Entry Name
Q6FH48_HUMAN
NCBI Summary for ASPA
This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ASPA
ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Defects in ASPA are the cause of Canavan disease (CAND); also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein type: Hydrolase; EC 3.5.1.15; Amino Acid Metabolism - histidine; Amino Acid Metabolism - alanine, aspartate and glutamate
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; hydrolase activity, acting on ester bonds; aspartoacylase activity; aminoacylase activity
Biological Process: myelination in the central nervous system; aspartate catabolic process; positive regulation of oligodendrocyte differentiation
Disease: Canavan Disease
Research Articles on ASPA
1. report of 2 Egyptian sibling patients suspected of Canavan disease (CD); study revealed homozygosity for substitution T530C (Ile177Thr) in exon 4 of the ASPA gene in both sibs; substitution T530C (Ile177Thr) results in a novel missense mutation causing a CD phenotype with severe clinical characteristics
Precautions
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