Product Name
MyD88, Peptide
Full Product Name
MyD88 Blocking Peptide
Product Gene Name
MyD88 peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6Y1S1
Form/Format
50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
Concentration
0.5 mg/ml (lot specific)
Handling
The peptide solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of MyD88 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for MyD88 peptide
Antibodies & Supporting Tools; Blocking Peptides
Applications Tested/Suitable for MyD88 peptide
Western Blot (WB)
Application Notes for MyD88 peptide
The peptide is used for blocking the antibody activity of MyD88. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.
NCBI/Uniprot data below describe general gene information for MyD88. It may not necessarily be applicable to this product.
NCBI Accession #
NP_937763.1
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NCBI GenBank Nucleotide #
NM_198130.1
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UniProt Primary Accession #
Q6Y1S1
[Other Products]
UniProt Secondary Accession #
Q4QRC0[Other Products]
UniProt Related Accession #
Q6Y1S1[Other Products]
Molecular Weight
33,856 Da
NCBI Official Full Name
myeloid differentiation primary response protein MyD88
NCBI Official Synonym Full Names
myeloid differentiation primary response 88
NCBI Official Symbol
Myd88 [Similar Products]
NCBI Protein Information
myeloid differentiation primary response protein MyD88
UniProt Protein Name
Myeloid differentiation primary response protein MyD88
Protein Family
Myeloid differentiation primary response protein
UniProt Gene Name
Myd88 [Similar Products]
UniProt Entry Name
MYD88_RAT
NCBI Summary for MyD88
an adaptor protein which binds toll-like receptors and links them to other downstream signalling molecules [RGD, Feb 2006]
UniProt Comments for MyD88
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine ().
Research Articles on MyD88
1. Propofol 10 muM but not lower clinically relevant or higher supra-clinical concentrations attenuated LPS-induced astrocyte activation and subsequent inflammatory responses by inhibiting the TLR4/MyD88-dependent NF-kappaB, ERK1/2, and p38 MAPK pathways.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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