RP9, Recombinant Protein

RP9 protein (His tag)

For Research Use Only. Not for use in diagnostic procedures.

Human

> 85% pure

Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol, 1mM DTT

500 ug/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of RP9 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Neuroscience

SDS-PAGE

Figure annotation denotes ug of protein loaded and % gel used.

26,107 Da

retinitis pigmentosa 9 (autosomal dominant)

retinitis pigmentosa 9 protein

Retinitis pigmentosa 9 protein

PAP-1  [Similar Products]

The protein encoded by this gene can be bound and phosphorylated by the protooncogene PIM1 product, a serine/threonine protein kinase . This protein localizes in nuclear speckles containing the splicing factors, and has a role in pre-mRNA splicing. CBF1-interacting protein (CIR), a corepressor of CBF1, can also bind to this protein and effects alternative splicing. Mutations in this gene result in autosomal dominant retinitis pigmentosa-9. This gene has a pseudogene (GeneID: 441212), which is located in tandem array approximately 166 kb distal to this gene. [provided by RefSeq, Sep 2009]

RP9: Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1. Defects in RP9 are the cause of retinitis pigmentosa type 9 (RP9). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP9 inheritance is autosomal dominant.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: cognition; RNA splicing

Disease: Retinitis Pigmentosa 9

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