Full Product Name
CCR9 (C-C chemokine receptor type 9, CC-CKR-9, C-C CKR-9, CCR-9, CDw199, GPR28, GPR-9-6, G-protein coupled receptor 28)
Product Synonym Names
Anti -CCR9 (C-C chemokine receptor type 9, CC-CKR-9, C-C CKR-9, CCR-9, CDw199, GPR28, GPR-9-6, G-protein coupled receptor 28)
Product Gene Name
anti-CCR9 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 3; NC_000003.11 (45927996..45944667). Location: 3p21.3
3D Structure
ModBase 3D Structure for P51686
Specificity
Recognizes mouse CDw199.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Immunogen
25 aa from the amino terminal of murine CCR9, coupled to KLH.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CCR9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CCR9 antibody
Antibodies; Abs to G Protein Receptors
Applications Tested/Suitable for anti-CCR9 antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CCR9 antibody
Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 1:25-1:200; 10ul labels 10e6 cells in 100ul
NCBI/Uniprot data below describe general gene information for CCR9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006632.2
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NCBI GenBank Nucleotide #
NM_006641.3
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UniProt Primary Accession #
P51686
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UniProt Secondary Accession #
Q4VBM3; Q549E0; Q9UQQ6[Other Products]
UniProt Related Accession #
P51686; Q9UN87[Other Products]
Molecular Weight
42,016 Da[Similar Products]
NCBI Official Full Name
C-C chemokine receptor type 9 isoform B
NCBI Official Synonym Full Names
chemokine (C-C motif) receptor 9
NCBI Official Symbol
CCR9 [Similar Products]
NCBI Official Synonym Symbols
GPR28; CDw199; GPR-9-6
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NCBI Protein Information
C-C chemokine receptor type 9; CC-CKR-9; OTTHUMP00000164653; OTTHUMP00000164654; G protein-coupled receptor 28
UniProt Protein Name
C-C chemokine receptor type 9
UniProt Synonym Protein Names
G-protein coupled receptor 28; GPR-9-6
Protein Family
C-C chemokine receptor
UniProt Gene Name
CCR9 [Similar Products]
UniProt Synonym Gene Names
GPR28 [Similar Products]
UniProt Entry Name
CCR9_HUMAN
NCBI Summary for CCR9
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. [provided by RefSeq]
UniProt Comments for CCR9
CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: C-C chemokine receptor activity; chemokine receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; immune response; chemotaxis
Research Articles on CCR9
1. CCR9+ Th cells are a subset of IL-21-producing T helper cells that influence regional specification of autoimmune diseases that affect accessory organs of the digestive system
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
