CYP51A1, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>=95% as determined by SDS-PAGE
Immunogen Affinity Purified

Liquid

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-CYP51A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)

46,312 Da

cytochrome P450 family 51 subfamily A member 1

lanosterol 14-alpha demethylase

Lanosterol 14-alpha demethylase

CYP51; LDM; Cytochrome P45014DM  [Similar Products]

CP51A_HUMAN

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; EC 1.14.13.70; Lipid Metabolism - steroid biosynthesis

Chromosomal Location of Human Ortholog: 7q21.2

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; plasma membrane

Molecular Function: heme binding; iron ion binding; sterol 14-demethylase activity

Biological Process: cholesterol biosynthetic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol; steroid biosynthetic process; sterol metabolic process

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