SH3BP2, Polyclonal Antibody

Anti -SH3BP2, phosphorylated (Ser427) (SH3 domain-binding protein 2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000004.11 (2794750..2842823). Location: 4p16.3

Polyclonal

IgG

Rabbit

Recognizes human SH3BP2 gene protein when phosphorylated at pS427.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins added.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-SH3BP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Phosphorylation of SH3BP2 occurs on S427 for activation. SH3BP2 mediates interactions of huntingtin and MLK2 (mixed lineage kinase).

Antibodies; Abs to Proteins

ELISA (EL/EIA)

Suitable for use in ELISA.
Dilution: ELISA: 1:2000-1:6000

62,244 Da[Similar Products]

SH3-domain binding protein 2

SH3 domain-binding protein 2; OTTHUMP00000219014; OTTHUMP00000219024; OTTHUMP00000219026; OTTHUMP00000219027; Abl-SH3 binding protein 2; TNFAIP3 interacting protein 2

SH3 domain-binding protein 2

3BP2  [Similar Products]

3BP2_HUMAN

The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

SH3BP2: an adaptor protein that binds differentially to the SH3 domains of certain proteins. Links the hemopoietic tyrosine kinase Fes to the cytoplasmic membrane in a phosphorylation dependent manner. Regulates FC-epsilon RI -mediated degranulation in rat basophilic leukemia RBL-2H3 cells. Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas. Defects in 3BP2 are the cause of cherubism, an autosomal dominant inherited syndrome. Two differentially spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4p16.3

Molecular Function: protein binding; SH3/SH2 adaptor activity; SH3 domain binding

Biological Process: positive regulation of signal transduction; signal transduction

Disease: Cherubism

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