ARHGAP26, Polyclonal Antibody

FLJ42530; GRAF; KIAA0621; OPHN1L; OPHN1L1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-ARHGAP26 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:5000
IHC: 1:20-1:200

86,165 Da

Rho GTPase activating protein 26

rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase pp125(FAK); oligophrenin-1-like protein

Rho GTPase-activating protein 26

GRAF; KIAA0621; OPHN1L  [Similar Products]

RHG26_HUMAN

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

ARHGAP26: GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Oncoprotein; GAPs, Rac/Rho; GAPs

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: focal adhesion; cytoskeleton; cytosol

Molecular Function: protein binding; phospholipid binding

Biological Process: nervous system development; regulation of small GTPase mediated signal transduction; plasma membrane organization and biogenesis; small GTPase mediated signal transduction; actin cytoskeleton organization and biogenesis

Disease: Juvenile Myelomonocytic Leukemia

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