Lathosterol Oxidase (LO), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of LO elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9348348 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lathosterol Oxidase (LO) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LO. The ELISA analytical biochemical technique of the MBS9348348 kit is based on LO antibody-LO antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LO antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LO. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

35,301 Da

sterol-C5-desaturase

lathosterol oxidase

Lathosterol oxidase

SC5DL  [Similar Products]

SC5D_HUMAN

This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

SC5DL: Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol. Defects in SC5DL are the cause of lathosterolosis (LATHST). This autosomal recessive disorder is characterized by a complex phenotype, including multiple congenital anomalies, mental retardation, and liver disease. Belongs to the sterol desaturase family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Lipid Metabolism - steroid biosynthesis; EC 1.14.21.6; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: C-5 sterol desaturase activity; iron ion binding

Biological Process: cholesterol biosynthetic process; cholesterol biosynthetic process via desmosterol; cholesterol biosynthetic process via lathosterol; fatty acid biosynthetic process; lipid metabolic process

Disease: Lathosterolosis

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