Product Name
Beta-ureidopropionase (Upb1), Recombinant Protein
Full Product Name
Recombinant Mouse Beta-ureidopropionase (Upb1)
Product Gene Name
Upb1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Upb1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-393aa, full length protein
Sequence
MAGPEWQSLE QCLEKHLPPD DLAQVKRILY GKQTRNLDLP REALKAASER NFELKGYAFG AAKEQQRCPQ IVRVGLVQNR IPLPTSAPVA EQVSALHKSI EEIAEVAAMC GVNIICFQEA WNMPFAFCTR EKLPWTEFAE SAEDGLTTRF CQKLAKKHNM VVVSPILERD REHGGVLWNT AVVISNSGLV MGKTRKNHIP RVGDFNESTY YMEGNLGHPV FQTQFGRIAV NICYGRHHPL NWLMYSINGA EIIFNPSATI GELSESLWPI EARNAAIANH CFTCALNRVG QEHFPNEFTS GDGKKAHHDL GYFYGSSYVA APDGSRTPGL SRNQDGLLVT ELNLNLCQQI NDFWTFKMTG RLEMYARELA EAVKPNYSPN IVKEDLVLAP SSG
3D Structure
ModBase 3D Structure for Q8VC97
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Upb1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Upb1 recombinant protein
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.
NCBI/Uniprot data below describe general gene information for Upb1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_598756.1
[Other Products]
NCBI GenBank Nucleotide #
NM_133995.4
[Other Products]
UniProt Primary Accession #
Q8VC97
[Other Products]
UniProt Secondary Accession #
Q8R1K8[Other Products]
UniProt Related Accession #
Q8VC97[Other Products]
Molecular Weight
43,937 Da
NCBI Official Full Name
beta-ureidopropionase
NCBI Official Synonym Full Names
ureidopropionase, beta
NCBI Official Symbol
Upb1 [Similar Products]
NCBI Official Synonym Symbols
AI195023
[Similar Products]
NCBI Protein Information
beta-ureidopropionase
UniProt Protein Name
Beta-ureidopropionase
UniProt Synonym Protein Names
Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase
Protein Family
Transcription factor
UniProt Gene Name
Upb1 [Similar Products]
NCBI Summary for Upb1
This gene encodes an enzyme that catalyzes the conversion of N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid or beta-alanine. Mutations in the related gene in human have been associated with beta-ureidopropionase deficiency. [provided by RefSeq, Dec 2013]
UniProt Comments for Upb1
Converts N-carbamoyl-beta-aminoisobutyrate and N-carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon dioxide.
Research Articles on Upb1
1. cloning and characterization of rat ortholog
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
