Product Name
PITX1, cDNA Clone
Full Product Name
PITX1 cDNA Clone
Product Gene Name
PITX1 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggacgcct tcaagggggg catgagcctg gagcggctgc cggaggggct ccggccgccg ccgccgccac cccatgacat ggggcccgcc ttccacctgg cccggcccgc cgacccccgc gagccgctcg agaactccgc cagcgagtcg tctgacacgg agctgccaga gaaggagcgc ggcggggaac ccaaggggcc cgaggacagt ggtgcgggag gcacgggctg cggcggcgca gacgacccag ccaagaagaa gaagcagcgg cggcaacgta cgcacttcac aagccagcag ttgcaagagc tagaggccac gttccagagg aaccgctacc ccgacatgag catgagggag gagatcgccg tgtggaccaa cctcaccgag ccgcgcgtgc gggtctggtt caagaaccgg cgagccaagt ggcgtaagcg cgagcgtaac cagcagctgg acctgtgcaa gggtggctac gtgccgcagt tcagcggcct agtgcagccc tacgaggacg tgtacgccgc cggctactcc tacaacaact gggccgccaa gagcctggcg ccagcgccgc tctccaccaa gagcttcacc ttcttcaact ccatgagccc gctgtcgtcg cagtccatgt tctcagcacc cagctccatc tcctccatga ccatgccgtc cagcatgggc ccaggcgccg tgcctggcat gcccaactcg ggcctcaaca acatcaacaa cctcaccggc tcctcgctca actcggccat gtcgccgggc gcttgcccgt acggcactcc cgcctcgccc tacagcgtct accgggacac gtgcaactcg agcctagcca gcctgcggct caagtccaaa cagcactcgt cgtttggcta cggcggcctg cagggcccgg cctcgggcct caacgcgtgc cagtacaaca gctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PITX1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PITX1. It may not necessarily be applicable to this product.
NCBI Accession #
BC009412
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UniProt Secondary Accession #
O14677; O60425; Q9BTI5; A8K3M0; D3DQB0[Other Products]
UniProt Related Accession #
P78337[Other Products]
Molecular Weight
34,128 Da
NCBI Official Full Name
Homo sapiens paired-like homeodomain 1, mRNA
NCBI Official Synonym Full Names
paired like homeodomain 1
NCBI Official Symbol
PITX1 [Similar Products]
NCBI Official Synonym Symbols
BFT; CCF; POTX; PTX1; LBNBG
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NCBI Protein Information
pituitary homeobox 1
UniProt Protein Name
Pituitary homeobox 1
UniProt Synonym Protein Names
Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1
Protein Family
Pituitary homeobox
UniProt Gene Name
PITX1 [Similar Products]
UniProt Synonym Gene Names
BFT; PTX1 [Similar Products]
UniProt Entry Name
PITX1_HUMAN
NCBI Summary for PITX1
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
UniProt Comments for PITX1
PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily.
Protein type: Cell development/differentiation; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 5q31.1
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding
Biological Process: anatomical structure morphogenesis; skeletal development
Disease: Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly; Liebenberg Syndrome
Research Articles on PITX1
1. To date, at least ten loci and four non-syndromic polydactyly-causing genes, including the GLI3 gene, the ZNF141 gene, the MIPOL1 gene and the PITX1 gene, have been identified. (Review)
Precautions
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Disclaimer
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