Full Product Name
MSX1/2 Antibody
Product Gene Name
anti-MSX1/2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28360
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-MSX1/2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MSX1/2 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MSX1/2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002439.2
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NCBI GenBank Nucleotide #
NM_002448.3
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UniProt Primary Accession #
P28360
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UniProt Secondary Accession #
Q96NY4; A0SZU5; A8K3M1[Other Products]
UniProt Related Accession #
P28360[Other Products]
Molecular Weight
31,496 Da
NCBI Official Full Name
homeobox protein MSX-1
NCBI Official Synonym Full Names
msh homeobox 1
NCBI Official Symbol
MSX1 [Similar Products]
NCBI Official Synonym Symbols
HOX7; HYD1; ECTD3; STHAG1
[Similar Products]
NCBI Protein Information
homeobox protein MSX-1
UniProt Protein Name
Homeobox protein MSX-1
UniProt Synonym Protein Names
Homeobox protein Hox-7; Msh homeobox 1-like protein
UniProt Gene Name
MSX1 [Similar Products]
UniProt Synonym Gene Names
HOX7 [Similar Products]
NCBI Summary for MSX1/2
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX1/2
MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.
Protein type: DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: p53 binding
Biological Process: cell morphogenesis; negative regulation of cell growth; odontogenesis of dentine-containing teeth; positive regulation of DNA damage response, signal transduction by p53 class mediator; protein stabilization
Disease: Orofacial Cleft 5; Tooth Agenesis, Selective, 1; Witkop Syndrome
Research Articles on MSX1/2
1. T; p.Pro247Ser and c.607G>A; p.Ala203Thr) in 2 Thai families; one is associated with preaxial polydactyly of the left hand, bilateral cleft lip and palate, hypodontia, microdontia and dens invaginatus; the other is associated with unilateral cleft lip and palate, microdontia and hypodontia">study reports 2 novel MSX1 mutations (c.739C>T; p.Pro247Ser and c.607G>A; p.Ala203Thr) in 2 Thai families; one is associated with preaxial polydactyly of the left hand, bilateral cleft lip and palate, hypodontia, microdontia and dens invaginatus; the other is associated with unilateral cleft lip and palate, microdontia and hypodontia
Precautions
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Disclaimer
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