MTAP, Polyclonal Antibody

S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}; 24228 {ECO:0000255|HAMAP-Rule:MF_03155}; 5'-methylthioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}; MTA phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}; MTAP {ECO:0000255|HAMAP-Rule:MF_03155}; MTAPase {ECO:0000255|HAMAP-Rule:MF_03155}; MTAP {ECO:0000255|HAMAP-Rule:MF_03155}; MSAP

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This MTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human MTAP.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-MTAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes an enzyme that plays a major role in
polyamine metabolism and is important for the salvage of both
adenine and methionine. The encoded enzyme is deficient in many
cancers because this gene and the tumor suppressor p16 gene are
co-deleted. Multiple alternatively spliced transcript variants have
been described for this gene, but their full-length natures remain
unknown.

Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

MTAP Antibody (N-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the MTAP antibody detected the MTAP protein (arrow).

31236

methylthioadenosine phosphorylase

S-methyl-5'-thioadenosine phosphorylase

S-methyl-5'-thioadenosine phosphorylase

MTA phosphorylase; MTAP; MTAPase  [Similar Products]

MTAP_HUMAN

This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

MTAP: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates. Homotrimer. Ubiquitously expressed. Inhibited by 5'-methylthiotubercin and 5'- chloroformycin. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Protein type: Phosphorylase; EC 2.4.2.28; Amino Acid Metabolism - cysteine and methionine; Transferase

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: phosphorylase activity; S-methyl-5-thioadenosine phosphorylase activity

Biological Process: methylation; methionine salvage; nicotinamide riboside catabolic process; sulfur amino acid metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; response to testosterone stimulus; purine ribonucleoside salvage; polyamine metabolic process

Newton-Bishop, J.A., et al. Cancer Epidemiol. Biomarkers Prev. 19(8):2043-2054(2010)
Yang, X.R., et al. Fam. Cancer (2010) In press :
Krasinskas, A.M., et al. Mod. Pathol. 23(4):531-538(2010)
Zhang, Q., et al. Zhonghua Liu Xing Bing Xue Za Zhi 31(1):83-86(2010)
Huang, H.Y., et al. Clin. Cancer Res. 15(22):6963-6972(2009)

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