Full Product Name
PITX1 Antibody
Product Synonym Names
Pituitary homeobox 1; Hindlimb-expressed homeobox protein backfoot; PITX1; BFT; PTX1
Product Gene Name
anti-PITX1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P78337
Species Reactivity
Human, Mouse, Rat
Specificity
PITX1 antibody detects endogenous levels of total PITX1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human PITX1.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-PITX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-PITX1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-PITX1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PITX1 antibody
WB: 1:500-1:1000
ELISA: 1:1000
Western Blot (WB) of anti-PITX1 antibody
Western blot analysis of extracts from Jurkat cells and COLO cells, using PITX1 antibody.
NCBI/Uniprot data below describe general gene information for PITX1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002644.4
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NCBI GenBank Nucleotide #
NM_002653.4
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UniProt Primary Accession #
P78337
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UniProt Secondary Accession #
O14677; O60425; Q9BTI5; A8K3M0; D3DQB0[Other Products]
UniProt Related Accession #
P78337[Other Products]
Molecular Weight
34,128 Da
NCBI Official Full Name
pituitary homeobox 1
NCBI Official Synonym Full Names
paired like homeodomain 1
NCBI Official Symbol
PITX1 [Similar Products]
NCBI Official Synonym Symbols
BFT; CCF; POTX; PTX1; LBNBG
[Similar Products]
NCBI Protein Information
pituitary homeobox 1
UniProt Protein Name
Pituitary homeobox 1
UniProt Synonym Protein Names
Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; Paired-like homeodomain transcription factor 1
Protein Family
Pituitary homeobox
UniProt Gene Name
PITX1 [Similar Products]
UniProt Synonym Gene Names
BFT; PTX1 [Similar Products]
NCBI Summary for PITX1
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
UniProt Comments for PITX1
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
Product References and Citations for anti-PITX1 antibody
Shang J., Genomics 40:108-113(1997). Schmutz J., Nature 431:268-274(2004). Olsen J.V., Cell 127:635-648(2006).
Research Articles on PITX1
1. we demonstrated a novel oncogenic mechanism of PTP1B on affecting PITX1/p120RasGAP in colorectal carcinoma(CRC). Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. PTP1B may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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