D Lactic Acid, ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of DLA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS035328 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the D Lactic Acid (DLA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DLA. The ELISA analytical biochemical technique of the MBS035328 kit is based on DLA antibody-DLA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DLA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DLA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

84,969 Da

deltaA

delta-like protein A

Delta-like protein A

DeltaA  [Similar Products]

DLLA_DANRE

Function: Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required for boundary formation during segmentation of the hindbrain. Required for midline cell fate specification prior to germ layer formation; regulates specification of floorplate, notochord and hypochord. In inner ear, it prevents adjacent cells from adopting the same cell fate. Plays a role in angiogenesis. Ref.1 Ref.4 Ref.5 Ref.8

Subunit structure: Interacts with mib. Ref.6

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Expressed in nervous system. In the developing nervous system, it is expressed in overlapping regions with deltaB (dlb) and deltaD (dld); in the neural plate, dla is expressed in patches of contiguous cells with dld, while dlb is confined to scattered cells within those patches that will differentiate as neurons. In 24 hours embryos, expressed in the hindbrain in stripes adjacent to rhombomere boundaries, but not in the actual boundary cells. During gastrulation and tail formation, expressed in embryonic midline cells. Expressed in hair cells of inner ear. Ref.1 Ref.3 Ref.4 Ref.7 Ref.8

Developmental stage: Initiated in the neuroectoderm before that of dld. In the developing trunk neural plate and neural tube, it is initiated in the epiblast prior to completion of gastrulation. At the 2- to 3-somite stage (10.5 hours) low levels are distributed throughout the trunk CNS, with cells expressing higher levels found in the medial and lateral regions of the neural plate. These regions correspond to the positions at which primary motoneurons and Rohon Beard neurons (RBs) originate. Cells expressing high levels do not form contiguous domains. Rather, single cells or small clusters of several cells showing high expression are interspersed with cells having lower expression. Expression is specific to the developing nervous system, and continues to be expressed broadly in the CNS throughout neurogenesis. Expressed in cells specified for neuronal fates. At 24 hours, and throughout later embryogenesis, it is broadly expressed in the spinal cord, suggesting that it is expressed by many types of cells. Expressed as neuronal specification occurs and is subsequently down-regulated in cells that have acquired specific neuronal fates. Ref.1

Post-translational modification: Ubiquitinated by mib, leading to its endocytosis and subsequent degradation. Ref.6

Sequence similarities: Contains 1 DSL domain.Contains 8 EGF-like domains.

Sequence caution: The sequence AAC41249.1 differs from that shown. Reason: Frameshift at position 726.

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