Isobutyryl-CoA Dehydrogenase, Mitochondrial (ACAD8), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ACAD8 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9359201 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Isobutyryl-CoA Dehydrogenase, Mitochondrial (ACAD8) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ACAD8. The ELISA analytical biochemical technique of the MBS9359201 kit is based on ACAD8 antibody-ACAD8 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ACAD8 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ACAD8. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

38,359 Da

acyl-CoA dehydrogenase family member 8

isobutyryl-CoA dehydrogenase, mitochondrial

Isobutyryl-CoA dehydrogenase, mitochondrial

ARC42; IBD; ARC42; ACAD-8  [Similar Products]

ACAD8_HUMAN

This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]

ACAD8: Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex. Defects in ACAD8 are the cause of isobutyryl-CoA dehydrogenase deficiency (IBDD). The symptoms of IBDD generally appear until late in infancy or in childhood and can include poor feeding and growth (failure to thrive), a weakened and enlarged heart (dilated cardiomyopathy), seizures, and low numbers of red blood cells (anemia). Belongs to the acyl-CoA dehydrogenase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Mitochondrial; EC 1.3.99.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding

Biological Process: branched chain family amino acid catabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis; lipid metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent; valine catabolic process

Disease: Isobutyryl-coa Dehydrogenase Deficiency

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