Product Name
beta I Tubulin (TUBB1), Polyclonal Antibody
Full Product Name
beta I Tubulin Antibody
Product Synonym Names
TUBB1; Beta tubulin 1; class VI; Tubulin; beta 1; Class VI beta-tubulin; DJ543J19.4; Tubulin beta-1 chain; Tubulin; beta 1 class VI
Product Gene Name
anti-TUBB1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H4B7
Species Reactivity
Human, Mouse, Rat, Cow, Dog, Monkey
Specificity
beta I Tubulin Antibody detects endogenous levels of total beta I Tubulin
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human beta I Tubulin
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-TUBB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TUBB1 antibody
Total protein Ab
Applications Tested/Suitable for anti-TUBB1 antibody
Western Blot (WB)
Application Notes for anti-TUBB1 antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-TUBB1 antibody
Western blot analysis beta I Tubulin using K562 whole cell lysates
NCBI/Uniprot data below describe general gene information for TUBB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_110400.1
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NCBI GenBank Nucleotide #
NM_030773.3
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UniProt Primary Accession #
Q9H4B7
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UniProt Related Accession #
Q9H4B7[Other Products]
Molecular Weight
50,327 Da[Similar Products]
NCBI Official Full Name
tubulin beta-1 chain
NCBI Official Synonym Full Names
tubulin beta 1 class VI
NCBI Official Symbol
TUBB1 [Similar Products]
NCBI Protein Information
tubulin beta-1 chain
UniProt Protein Name
Tubulin beta-1 chain
UniProt Gene Name
TUBB1 [Similar Products]
UniProt Entry Name
TBB1_HUMAN
NCBI Summary for TUBB1
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
UniProt Comments for TUBB1
TUBB1: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Interacts with RANBP10. Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins. Belongs to the tubulin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component: cytoplasm
Disease: Macrothrombocytopenia, Autosomal Dominant, Tubb1-related
Research Articles on TUBB1
1. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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