Product Name
GJA10 (GJA9), Polyclonal Antibody
Popular Item
Full Product Name
GJA10 Antibody (C-term)
Product Synonym Names
Gap junction alpha-9 protein; Connexin-58; Cx58; Connexin-59; Cx59; Gap junction alpha-10 protein; GJA9; GJA10
Product Gene Name
anti-GJA9 antibody
[Similar Products]
Antibody/Peptide Pairs
GJA10 peptide (MBS9221337) is used for blocking the activity of GJA10 antibody (MBS9203571)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
484-515
3D Structure
ModBase 3D Structure for P57773
Species Reactivity
Human, mouse
Specificity
This GJA10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-515 amino acids from the C-terminal region of human GJA10.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-GJA9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GJA9 antibody
GJA8 is a an integral membrane protein that belongs to the connexin family, alpha-type (group II) subfamily. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins.
Product Categories/Family for anti-GJA9 antibody
Signal Transduction
Applications Tested/Suitable for anti-GJA9 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-GJA9 antibody
WB~~1:1000
Western Blot (WB) of anti-GJA9 antibody
Western blot analysis of GJA10 Antibody (C-term) in mouse heart tissue lysates (35ug/lane). GJA10 (arrow) was detected using the purified Pab.
Immunohistochemistry (IHC) of anti-GJA9 antibody
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
NCBI/Uniprot data below describe general gene information for GJA9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_110399.2
[Other Products]
NCBI GenBank Nucleotide #
NM_030772.4
[Other Products]
UniProt Primary Accession #
P57773
[Other Products]
UniProt Secondary Accession #
Q5TA63; Q96KG0; B2R722; B3KVQ2[Other Products]
UniProt Related Accession #
P57773[Other Products]
NCBI Official Full Name
gap junction alpha-9 protein
NCBI Official Synonym Full Names
gap junction protein, alpha 9, 59kDa
NCBI Official Symbol
GJA9 [Similar Products]
NCBI Official Synonym Symbols
CX58; CX59; GJA10
[Similar Products]
NCBI Protein Information
gap junction alpha-9 protein
UniProt Protein Name
Gap junction alpha-9 protein
UniProt Synonym Protein Names
Connexin-58; Cx58; Connexin-59; Cx59; Gap junction alpha-10 protein
Protein Family
Gap junction alpha-9 protein
UniProt Gene Name
GJA9 [Similar Products]
UniProt Synonym Gene Names
GJA10; Cx58; Cx59 [Similar Products]
UniProt Entry Name
CXA9_HUMAN
NCBI Summary for GJA9
Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
UniProt Comments for GJA9
GJA9: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Alpha-type (group II) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p34
Cellular Component: connexon complex; integral to membrane
Biological Process: cell communication
Product References and Citations for anti-GJA9 antibody
Hombach S, et al., Eur J Neurosci. 2004 May;19(10):2633-40.
Houghton FD, et al., Biol Reprod. 2002 May;66(5):1403-12.
Manthey D, et al., J Biol Chem. 1999 May 21;274(21):14716-23.
Research Articles on GJA9
1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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