Product Name
ADD2, cDNA Clone
Full Product Name
ADD2 cDNA Clone
Product Gene Name
ADD2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGAGCGAAG AGACGGTCCC CGAGGCTGCC TCGCCGCCGC CCCCGCAGGG GCAGCCTTAC TTTGACCGCT TCTCAGAGGA CGACCCCGAG TACATGCGCC TTCGCAACCG GGCGGCGGAC CTGCGGCAGG ACTTCAACCT GATGGAGCAG AAGAAGCGCG TCACCATGAT CCTGCAGAGT CCCTCTTTCA GGGAGGAGCT GGAAGGCCTC ATCCAGGAGC AGATGAAGAA GGGGAACAAC TCCTCCAACA TCTGGGCCCT GCGACAGATC GCGGACTTCA TGGCCAGCAC CTCCCACGCA GTCTTCCCGA CATCTTCCAT GAATGTCTCC ATGATGACGC CTATCAATGA CCTCCACACA GCTGACTCCC TGAACCTGGC CAAAGGGGAG CGGCTCATGC GGTGCAAGAT CAGCAGTGTC TACCGACTCC TGGACCTCTA TGGCTGGGCC CAGCTGAGTG ACACCTATGT CACGTTGAGA GTCAGCAAGG AGCAGGACCA CTTCCTGATC AGCCCTAAGG GAGTTTCTTG CAGTGAAGTC ACAGCGTCCA GCCTGATCAA GGTGAACATT CTGGGAGAGG TGGTGGAGAA GGGCAGCAGC TGCTTCCCAG TGGACACCAC AGGCTTCTGT CTGCACTCGG CCATCTATGC AGCGAGGCCC GACGTGCGCT GCATCATCCA CCTGCACACA CCGGCCACAG CAGCGGTGTC GGCCATGAAG TGGGGCCTCC TGCCTGTCTC CCACAATGCC CTGCTGGTGG GGGACATGGC CTATTATGAC TTCAATGGGG AAATGGAGCA GGAAGCCGAT CGGATCAACC TGCAGAAGTG CCTTGGACCC ACCTGCAAGA TCCTGGTGCT AAGAAACCAT GGAGTGGTTG CTCTGGGTGA CACGGTAGAG GAGGCATTTT ACAAGATCTT CCACCTGCAG GCTGCATGTG AGATACAGGT GTCGGCTCTG TCCAGTGCCG GGGGAGTGGA GAACCTCATC CTCCTGGAGC AGGAGAAGCA CCGGCCCCAT GAGGTGGGCT CCGTGCAGTG GGCCGGGAGC ACCTTTGGGC CTATGCAGAA GAGTCGGCTG GGGGAGCATG AGTTTGAGGC CCTCATGAGG ATGCTGGACA ACCTGGGCTA CAGAACAGGT TACACGTATC GCCACCCCTT TGTTCAAGAG AAAACCAAAC ACAAAAGTGA GGTGGAGATT CCAGCCACGG TCACAGCCTT CGTGTTTGAG GAGGACGGTG CCCCGGTGCC CGCCCTGCGA CAGCATGCCC AGAAGCAGCA GAAGGAGAAG ACCCGCTGGC TCAATACGCC CAACACCTAC CTGCGGGTCA ATGTGGCCGA TGAGGTCCAG AGGAGCATGG GCAGCCCCCG ACCCAAGACC ACGTGGATGA AGGCTGACGA GGTGGAGAAA TCCAGCAGTG GCATGCCGAT TCGCATCGAA AACCCAAACC AATTTGTGCC TCTCTATACT GACCCCCAGG AAGTACTGGA GATGAGGAAC AAGATTCGAG AACAAAACCG ACAAGATGTG AAGTCAGCGG GGCCTCAGTC CCAGCTCCTG GCGAGCGTCA TTGCCGAGAA GAGCCGAAGC CCGTCTACAG AGAGCCAGCT GATGTCCAAG GGAGACGAGG ATACCAAAGA CGATTCAGAG GAGACGGTGC CCAACCCCTT CAGCCAACTC ACTGACCAGG AGTTGGAGGA GTACAAGAAA GAGGTGGAGA GGAAGAAACT AGAACTTGAT GAGACAGGAC AGGAACGAGA GCCAGGCTCT GGTCCGGCCG TGTGCGAGTT CTTCAGCGTT GCCCTCCACA TCTGGAGTAA CATATTGGAG AGAAAGAAAC TGCCCCAGAA GAGCCTGGCT CACCTGCAAA GTCTGCACCT GCTTCTCCAG TGCAGAGCCC AGCGAAGGAG GCAGAGACAA AGAGCCCTTT AG
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ADD2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ADD2. It may not necessarily be applicable to this product.
NCBI Accession #
BC041666
[Other Products]
UniProt Secondary Accession #
Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; A8K4P2; B4DM17; D6W5G7; D6W5G8[Other Products]
UniProt Related Accession #
P35612[Other Products]
Molecular Weight
64,217 Da
NCBI Official Full Name
Homo sapiens adducin 2 (beta), mRNA
NCBI Official Synonym Full Names
adducin 2
NCBI Official Symbol
ADD2 [Similar Products]
NCBI Official Synonym Symbols
ADDB
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NCBI Protein Information
beta-adducin
UniProt Protein Name
Beta-adducin
UniProt Synonym Protein Names
Erythrocyte adducin subunit beta
Protein Family
Aminodeoxyfutalosine deaminase
UniProt Gene Name
ADD2 [Similar Products]
UniProt Synonym Gene Names
ADDB [Similar Products]
UniProt Entry Name
ADDB_HUMAN
NCBI Summary for ADD2
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
UniProt Comments for ADD2
ADD2: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Beta-adducin is restricted to brain and hematopoietic tissues. Three alternatively-spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: cytoplasmic membrane-bound vesicle; cytosol; F-actin capping protein complex
Molecular Function: actin binding; actin filament binding; protein heterodimerization activity; protein homodimerization activity; spectrin binding
Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; barbed-end actin filament capping; positive regulation of protein binding; protein complex assembly; transmembrane transport
Research Articles on ADD2
1. Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1-mediated neutrophil rolling on P-selectin.
Precautions
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Disclaimer
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